The "rings of fire" and thyroid cancer

Duntas, Leonidas H.; D̲oumas, Christos

doi:10.14310/horm.2002.1242

Cited by 45 publications

(20 citation statements)

References 21 publications

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“…A plausible explanation may be represented by the differences between the two populations studied. While in The Netherlands, the incidence of TC is low (Netea-Maier et al 2008), this is far higher in Iceland (Duntas & Doumas 2009). The volcanic nature of Iceland has been invoked as a potential culprit, as the incidence of TC in Iceland is much higher than that in the founder populations from Denmark and Sweden (Kilfoy et al 2009).…”

Section: Dear Editormentioning

confidence: 99%

The effect of the ATG16L1 Thr300Ala polymorphism on susceptibility and outcome of patients with epithelial cell-derived thyroid carcinoma

Huijbers¹,

Plantinga²,

Joosten³

et al. 2012

Endocrine-Related Cancer

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Section: Dear Editormentioning

confidence: 99%

The effect of the ATG16L1 Thr300Ala polymorphism on susceptibility and outcome of patients with epithelial cell-derived thyroid carcinoma

Huijbers¹,

Plantinga²,

Joosten³

et al. 2012

Endocrine-Related Cancer

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“…As a matter of fact, Neapolitan patients mainly came from the areas around the volcano Vesuvius and Campi Flegrei, which are exposed to volcanic minerals, according to ARPA data [25]. Therefore, this phenomenon of age anticipation could be related to the exposure to one or more volcanic carcinogens (in particular heavy metals) [21][22][23][32][33][34][35][36]. It has already been reported that high heavy metal concentration in the soil or water would act as endocrine disruptors, increasing the risk for thyroid cancer in younger age because their [37].…”

Section: Discussionmentioning

confidence: 99%

How do etiological factors can explain the different clinical features of patients with differentiated thyroid cancer and their histopathological findings?

et al. 2016

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The aim was to retrospectively analyse the clinical-histopathological characteristics of patients with newly diagnosis of differentiated thyroid cancer (DTC) referred to two Italian centres, one in Northern and the other in Southern Italy, between 2000 and 2013. 1081 patients were included and subdivided into two groups: group A (474 patients from Novara) and group B (607 patients from Naples). The group A came from the industrial area of Novara, while the Group B came from the areas around Vesuvius and Campi Flegrei. The two groups were comparable for iodine levels, body mass index, diagnostic timing and clinical procedures. For all patients, demographic and clinical data were collected. No difference was found in gender, whereas the age at diagnosis was later in the group A (group A 53.1 ± 15.16 years, group B 41.9 ± 14.25 years, p < 0.001). In both groups, the most frequent histotype was papillary thyroid cancer (PTC) with prevalence of follicular variant in group A (p < 0.0001) and classical variant in group B (p < 0.0001). Aggressive histological features were mainly seen in group A (bilaterality p < 0.0001, multifocality p < 0.0001 and thyroid capsular invasion p < 0.0001). Microcarcinomas were more frequent in group A (p < 0.0001) but mostly characterized by bilaterality (p < 0.001) and multifocality (p < 0.04). In both groups, tumour-associated thyroiditis showed a significant increase over the years (group A p < 0.05, group B p < 0.04). Environmental factors could justify the differences found in our study. These preliminary data should stimulate the need for an Italian Cancer Registry of DTC in order to allow an epidemiological characterization, allowing the identification of specific etiological factors and an improvement in the management of the disease.

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“…Therefore, it is highly possible that the higher risk of DNA damage in the buccal epithelia of Furnas' inhabitants is mainly associated with exposure to the high concentrations of residential Rn. In a recent review that analyzes the increased incidence of thyroid cancer in volcanic areas around the world, Duntas and Doumas (2009) refer the presence of Cd and radioactivity as factors potentially involved in thyroid tumorigenesis in volcanic regions. In Furnas village, Cd, Cu, Pb, Rb and Zn are usually present in volcanic emissions, and there seems to be evidence for a high bioavailability of these elements as shown by their concentrations in the scalp hair of its inhabitants (Amaral et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Evidence of DNA damage in humans inhabiting a volcanically active environment: A useful tool for biomonitoring

Rodrigues¹,

Arruda

Garcia

2012

Environment International

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. The present study was designed to evaluate whether chronic exposure to a volcanically active environment might result in genotoxic and cytotoxic effects in human oral epithelial cells. A study group of 120 individuals inhabiting a volcanically active environment (exposed group; Furnas village) and a reference group of 122 individuals inhabiting a village without manifestations of volcanic activity (Santo António village) were examined in this study. Individuals from Furnas village inhabit a volcanically active environment marked by several degassing manifestations, including fumarolic fields, thermal and cold CO 2 springs and soil diffuse degassing areas. For each individual, 1000 buccal epithelial cells were analyzed for the frequency of micronucleated cells (MNC) and the frequency of cells with other nuclear anomalies (ONA: pyknosis, karyolysis and karyorrhexis), by using the micronucleus assay. Information on life-style factors and an informed consent were obtained from each participant. The frequencies of MNC and of ONA per 1000 cells in the exposed group (4.3‰ and 23.5‰, respectively) were significantly higher than in the reference group (1.7‰ and 7.7‰, respectively). The risk of having a high frequency of MNC or ONA was 2.4 and 3.1-fold higher in exposed individuals compared to reference group. The analyzed confounding factors (age, gender, smoking status, alcohol consumption, and mouthwash use) did not show any significant association with the frequency of MNC or ONA. The higher risk of DNA damage in individuals inhabiting a volcanically active environment is for the first time clearly highlighted with this biomonitoring study. Given that MNC in oral epithelia are recognized as a predictive biomarker of cancer risk within a population of healthy subjects, these findings could contribute to explain the high incidence rates of lip, oral cavity and pharynx cancers previously referred for Furnas village inhabitants.

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The "rings of fire" and thyroid cancer

Cited by 45 publications

References 21 publications

The effect of the ATG16L1 Thr300Ala polymorphism on susceptibility and outcome of patients with epithelial cell-derived thyroid carcinoma

The effect of the ATG16L1 Thr300Ala polymorphism on susceptibility and outcome of patients with epithelial cell-derived thyroid carcinoma

How do etiological factors can explain the different clinical features of patients with differentiated thyroid cancer and their histopathological findings?

Evidence of DNA damage in humans inhabiting a volcanically active environment: A useful tool for biomonitoring

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