“…We previously cloned the complementary DNA (cDNA) of PDZRN3 from a human heart library with the use of a yeast two‐hybrid screen for proteins that bind to the PDZ domains of PSD‐95 (Ko et al, ). PDZRN3 is expressed in a variety of human tissues including heart, skeletal muscle, brain, and liver (Ko et al, ), and it has been implicated in various developmental processes including the differentiation of myoblasts (Ko et al, ), osteoblasts (Honda, Yamamoto, Ishii, & Inui, ), and adipocytes (Honda, Ishii, & Inui, ) as well as formation of neuromuscular junctions (Lu et al, ), neurogenesis (Andreazzoli et al, ), vascular morphogenesis (Sewduth et al, ), maintenance of the integrity of endothelial intercellular junctions (Sewduth et al, ), and regulation of paracellular Mg 2+ flux in renal tubular epithelial cells (Marunaka et al, ).…”