The right touch: design of artificial antigen-presenting cells to stimulate the immune system

Weijden, Jessica van der; Paulis, Leonie E. M.; Verdoes, Martijn; Hest, Jan C. M. van; Figdor, Carl G.

doi:10.1039/c4sc01112k

Cited by 41 publications

(39 citation statements)

References 106 publications

(145 reference statements)

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“…Different aAPC designs have been synthesized over the last years with scaffolds varying from polymer beads, 3,4 carbon nanotubes, 5 liposomes, 6 and many others. 7 In general, the design of aAPCs is inspired by the natural DC and its interaction with the T cell. DC binding to T cells involves three main signals that are all required to fully activate the T cell: antigen-loaded major histocompatibility complexes (pMHC) of the DC bind to specific T-cell receptors (TCR; signal 1).…”

Section: Introductionmentioning

confidence: 99%

Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect

et al. 2017

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Artificial antigen-presenting cells (aAPCs) have recently gained a lot of attention. They efficiently activate T cells and serve as powerful replacements for dendritic cells in cancer immunotherapy. Focusing on a specific class of polymer-based aAPCs, so-called synthetic dendritic cells (sDCs), we have investigated the importance of multivalent binding on T-cell activation. Using antibody-functionalized sDCs, we have tested the influence of polymer length and antibody density. Increasing the multivalent character of the antibody-functionalized polymer lowered the effective concentration required for T-cell activation. This was evidenced for both early and late stages of activation. The most important effect observed was the significantly prolonged activation of the stimulated T cells, indicating that multivalent sDCs sustain T-cell signaling. Our results highlight the importance of multivalency for the design of aAPCs and will ultimately allow for better mimics of natural dendritic cells that can be used as vaccines in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect

et al. 2017

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“…With the ever‐expanding possibilities to build supramolecular structures, chemists are challenged to mimic nature in which construction of artificial cells and realization of their functions has been one of the most attractive tasks . Till now, macromolecular self‐assembly has been quite an important strategy used by chemists aiming at artificial cell due to the stability and functionality of the self‐assembled polymeric structures in a scale range from nanometer to millimeter.…”

Section: Introductionmentioning

confidence: 99%

Glycocalyx‐Mimicking Nanoparticles for Stimulation and Polarization of Macrophages via Specific Interactions

Zhang

et al. 2015

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Malignant tumors develop multiple mechanisms to impair and escape from antitumor immune responses, of which tumor-associated macrophages that often show immunosuppressive phenotype (M2), play a critical role in tumor-induced immunosuppression. Therefore, strategies that can reverse M2 phenotype and even enhance immune-stimulation function of macrophage would benefit tumor immunotherapy. In this paper, self-assembled glyco-nanoparticles (glyco-NPs), as artificial glycocalyx, have been found to be able to successfully induce the polarization of mouse primary peritoneal macrophages from M2 to inflammatory type (M1). The polarization change was evidenced by the decreased expression of cell surface signaling molecules CD206 and CD23, and the increased expression of CD86. Meanwhile, secretion of cytokines supported this polarization change as well. More importantly, this phenomenon is observed not only in vitro, but also in vivo. As far as we known, this is the first report about macrophage polarization being induced by synthetic nanomaterials. Moreover, preparation, characterization of these glyco-NPs and their interaction with the macrophages are also demonstrated.

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“…If the goal of the NV is to accomplish interaction with the immune system in order to facilitate, for example, T-cell activation then effective display and accessibility of surface motifs is highly important and these should not become deactivated in biological medium [38]. Alternatively, if drug release or enzyme delivery is the desired NV function then control over the way in which the active agent is released in time, and also in space, is very important.…”

Section: Rd Generation (Work In Progress): Targeted Nanovectorsmentioning

confidence: 99%

Controlling the morphology of copolymeric vectors for next generation nanomedicine

Williams

Pijpers

Ridolfo

et al. 2017

Journal of Controlled Release

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The right touch: design of artificial antigen-presenting cells to stimulate the immune system

Cited by 41 publications

References 106 publications

Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect

Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect

Glycocalyx‐Mimicking Nanoparticles for Stimulation and Polarization of Macrophages via Specific Interactions

Controlling the morphology of copolymeric vectors for next generation nanomedicine

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