The right to the theatre

Zaiontz, Keren

doi:10.1017/cbo9781139629119.033

Cited by 10 publications

(11 citation statements)

References 5 publications

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“…Statistical analysis was carried out with the add-in Real Statistics release 7.6 in Excel 2016 . ANOVA (α = 0.05) and Tukey’s test were used to test for statistical significances between groups.…”

Section: Methodsmentioning

confidence: 99%

Characterization and Quantification of Mal d 1 Isoallergen Profiles and Contents in Traditional and Commercial Apple Varieties by Mass Spectrometry

Kaeswurm

Straub

Siegele³

et al. 2023

J. Agric. Food Chem.

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The apple allergy in Northern Europe is a cross-reaction to the birch pollen allergy. No correlation between the allergenicity of an apple variety and the content of the major apple allergen Mal d 1, a homologue to the Bet v 1 allergen in birch, could be found using ELISA, so far. Therefore, an impact of polyphenols and/or differences in the isoallergen profile are discussed. To allow a more detailed analysis of the Mal d 1 content and the isoallergen profile, a mass spectrometric method was applied to investigate differences in the flesh and peel of 10 traditional varieties and 10 commercial breeds. The data revealed often, but not always, lower Mal d 1 contents in traditional varieties grown in orchard meadows, which was more obvious in the flesh. Differences among the peels were less pronounced. A closer look at the individual isoallergens 1.01, 1.02, 1.03, and 1.06 reveals an increased impact of the minor isoallergens 1.03 and 1.06 on the allergenic potential, since commercial breeds like Braeburn, Santana, and Holstein Cox, which are considered to have reduced allergenic potentials, were characterized by low levels of these isoallergens.

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Section: Methodsmentioning

confidence: 99%

Characterization and Quantification of Mal d 1 Isoallergen Profiles and Contents in Traditional and Commercial Apple Varieties by Mass Spectrometry

Kaeswurm

Straub

Siegele³

et al. 2023

J. Agric. Food Chem.

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“…Data analyses and quantification were done using SKYLINE (Version 21.1.0.146, MacCoss Lab, Department of Genome Science, UW). Statistical analysis was carried out with the add-in Real Statistics release 7.6 in Excel 2016 . Data were checked for normality and homogeneity of variance by Shapiro–Wilk and Levene’s test, respectively.…”

Section: Methodsmentioning

confidence: 99%

New Mass Spectrometric Approach to Quantify the Major Isoallergens of the Apple Allergen Mal d 1

Kaeswurm

Straub

Klußmann

et al. 2022

J. Agric. Food Chem.

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Patients who suffer from birch pollinosis often develop adverse reactions to the consumption of fresh apples due to the structural similarity of the allergens Bet v 1 and Mal d 1 from birch and apples, respectively. A different allergenic potential for Mal d 1 isoallergens is postulated, but approaches to quantify the Mal d 1 isoallergen-specific are missing. Therefore, a bottom-up proteomics approach was developed to quantify Mal d 1 by stable isotope dilution and microHPLC-QTOF analyses. Marker peptides for individual isoallergens (Mal d 1.01–Mal d 1.03 and Mal d 1.06), combinations thereof (Mal d 1.01 + 1.02, Mal d 1.02 + 1.06, and Mal d 1.04 + 1.05), and two global marker peptides, comprising Mal d 1.01 + 1.02 + 1.04 + 1.05 and Mal d 1.03 + 1.06 + 1.07 + 1.08 + 1.09, were identified. By the use of an extraction standard (r-Mal d 1_mut), an optimized protocol for extraction and tryptic digestion of apple proteins was developed, and the variety-specific extraction efficiency was monitored for the flesh and peel of apples. The Mal d 1 contents in flesh and peel of five commercial apple breeds and four apple varieties from orchard meadows were quantified isoallergen-specific.

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“…Based on these effect sizes, the statistical power ratios of the analyses were calculated using the Real Statistics Resource Pack. 24 In the analyses, the level of significance was accepted as 5%, the degree of freedom was accepted as 5 for the PSQI, 20 for daytime dysfunction, and 15 for the other 6 components. According to the results obtained, the effect sizes ranged from 0.32 to 0.58.…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Relationship between Vestibular Disorders and Sleep Disturbance

Mutlu

Topcu

2022

Int Arch Otorhinolaryngol

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Introduction Vestibular pathologies cause physical and psychological symptoms, as well as cognitive problems. Objective To evaluate the deterioration in sleep quality associated with vestibular pathologies. Methods The Dizziness Handicap Inventory (DHI), the Beck Depression Inventory (BDI), the Pittsburgh Sleep Quality Index (PSQI), and the Limits of Stability test (LOS) were applied to the participants. Results We included 25 patients with Meniere's disease (MD), 22 patients with benign paroxysmal positional vertigo (BPPV), 21 patients with unilateral peripheral vestibular loss (UPVL), 23 patients with vestibular migraine (VM), and 43 controls. The total PSQI scores of the controls were better than those of the MD (p = 0.014), VM (p < 0.001), BPPV (p = 0.003), and UPVL (p = 0.001) groups. The proportion of poor sleepers in the MD (p = 0.005), BPPV (p = 0.018), and UPVL (p < 0.001) groups was significantly higher than that of the controls. The highest total DHI score (45.68 ± 25.76) was found among the MD group, and it was significantly higher than the scores of the BPPV (p = 0.007) and control (p < 0.001) groups. The highest BDI score was obtained in the VM group, and it was significantly higher than the scores of the BPPV (p = 0.046) and control (p < 0.001) groups. Moreover, the BDI scores of the MD (p = 0.001) and UPVL groups were also significantly worse than the score of the controls (p = 0.001). Conclusion The present study showed thatpatients with vestibular symptoms have physical and functional complaints, as well as increased psychosocial stress and decreased sleep quality. Evaluating multiple parameters of quality of life may contribute to a better understanding of vestibular physiology and symptoms, and may help establish a more effective therapeutic approach.

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The right to the theatre

Cited by 10 publications

References 5 publications

Characterization and Quantification of Mal d 1 Isoallergen Profiles and Contents in Traditional and Commercial Apple Varieties by Mass Spectrometry

Characterization and Quantification of Mal d 1 Isoallergen Profiles and Contents in Traditional and Commercial Apple Varieties by Mass Spectrometry

New Mass Spectrometric Approach to Quantify the Major Isoallergens of the Apple Allergen Mal d 1

Investigation of the Relationship between Vestibular Disorders and Sleep Disturbance

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