The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention

Iskander, Andrew; Bilgi, Coşkun; Naftalovich, Rotem; Hacihaliloglu, Ilker; Berkman, Tolga; Naftalovich, Daniel; Pahlevan, Niema M.

doi:10.3389/fbioe.2021.678048

Cited by 5 publications

(1 citation statement)

References 125 publications

(160 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also utilized Newtonian flow assumption for the fluid in this study. This assumption is still conventionally used in both experimental and CFD studies in large arteries ( Iskander et al, 2021 ). However, future studies are needed to investigate the significance of non-Newtonian flow behavior in TBAD modeling in terms of FL flow reversal after TEVAR.…”

Section: Discussionmentioning

confidence: 99%

Model-Based Fluid-Structure Interaction Approach for Evaluation of Thoracic Endovascular Aortic Repair Endograft Length in Type B Aortic Dissection

Aghilinejad

Wei

Magee

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Thoracic endovascular aortic repair (TEVAR) is a commonly performed operation for patients with type B aortic dissection (TBAD). The goal of TEVAR is to cover the proximal entry tear between the true lumen (TL) and the false lumen (FL) with an endograft to induce FL thrombosis, allow for aortic healing, and decrease the risk of aortic aneurysm and rupture. While TEVAR has shown promising outcomes, it can also result in devastating complications including stroke, spinal cord ischemia resulting in paralysis, as well as long-term heart failure, so treatment remains controversial. Similarly, the biomechanical impact of aortic endograft implantation and the hemodynamic impact of endograft design parameters such as length are not well-understood. In this study, a fluid-structure interaction (FSI) computational fluid dynamics (CFD) approach was used based on the immersed boundary and Lattice–Boltzmann method to investigate the association between the endograft length and hemodynamic variables inside the TL and FL. The physiological accuracy of the model was evaluated by comparing simulation results with the true pressure waveform measurements taken during a live TEVAR operation for TBAD. The results demonstrate a non-linear trend towards increased FL flow reversal as the endograft length increases but also increased left ventricular pulsatile workload. These findings suggest a medium-length endograft may be optimal by achieving FL flow reversal and thus FL thrombosis, while minimizing the extra load on the left ventricle. These results also verify that a reduction in heart rate with medical therapy contributes favorably to FL flow reversal.

show abstract

Section: Discussionmentioning

confidence: 99%

Model-Based Fluid-Structure Interaction Approach for Evaluation of Thoracic Endovascular Aortic Repair Endograft Length in Type B Aortic Dissection

Aghilinejad

Wei

Magee

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Euler-Lagrange numerical simulation of improved magnetic drug delivery in a three-dimensional CT-based carotid artery bifurcation

Aryan

Beigzadeh

Siavashi

2022

Computer Methods and Programs in Biomedicine

View full text Add to dashboard Cite

On the longitudinal wave pumping in fluid-filled compliant tubes

Aghilinejad,

Rogers,

Geng

et al. 2023

Physics of Fluids

View full text Add to dashboard Cite

This study investigates the physics of the longitudinal stretching-based wave pumping mechanism, a novel extension of the traditional impedance pump. In its simplest form, an impedance pump consists of a fluid-filled elastic tube connected to rigid tubes with a wave generator. These valveless pumps operate based on the principles of wave propagation in a fluid-filled compliant tube. Cardiovascular magnetic resonance imaging of the human circulatory system has shown substantial stretching of the aorta (the largest compliant artery of the body carrying blood) during the heart contraction and recoil of the aorta during the relaxation. Inspired by this dynamic mechanism, a comprehensive analysis of a longitudinal impedance pump is conducted in this study where waves are generated by stretching of the elastic wall and its recoil. We developed a fully coupled fluid–structure interaction computational model consisting of a straight fluid-filled elastic tube with longitudinal stretch at one end and a fixed reflection site at the other end. The pump's behavior is quantified as a function of stretching frequency and tube wall characteristics. Our results indicate that stretch-related wave propagation and reflection can induce frequency-dependent pumping. Findings suggest a non-linear pattern for the mean flow–frequency relationship. Based on the analysis of the propagated waveforms, the underlying physical mechanism in the longitudinal impedance pump is discussed. It is shown that both the direction and magnitude of the net flow strongly depend on the wave characteristics. These findings provide a fundamental understanding of stretch-related wave pumping and can inform the future design of such pumps.

show abstract

The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention

Cited by 5 publications

References 125 publications

Model-Based Fluid-Structure Interaction Approach for Evaluation of Thoracic Endovascular Aortic Repair Endograft Length in Type B Aortic Dissection

Model-Based Fluid-Structure Interaction Approach for Evaluation of Thoracic Endovascular Aortic Repair Endograft Length in Type B Aortic Dissection

Euler-Lagrange numerical simulation of improved magnetic drug delivery in a three-dimensional CT-based carotid artery bifurcation

On the longitudinal wave pumping in fluid-filled compliant tubes

Contact Info

Product

Resources

About