The rewarding properties of methamphetamine in an invertebrate model of drug addiction

Imeh-Nathaniel, Adebobola; Adedeji, Adekunle; Huber, Robert; Nathaniel, Thomas I.

doi:10.1016/j.physbeh.2015.10.017

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…In three different doses (2.5, 5.0, and 10.0 μg/g), methamphetamine induced a significant CPP for the hard-textured environment (Figure 2 ), with the higher doses (5.0 and 10.0 μg/g) of both drugs having a more pronounced effect of CPP. CPP was not established in the initially preferred soft textured environment when compared with the control group (Imeh-Nathaniel et al, 2016 ). Similarly, in a study investigating the effects of different visual cues on CPP when paired with morphine, crayfish initially showed an unconditioned preference for a white walled environment (Dziopa et al, 2011 ).…”

Section: Novel Stimuli Directly Augment Exploration and Appetitive Momentioning

confidence: 99%

“…This indicates that the dopamine-mediated appetitive motivational states stimulated by drugs of addiction, conditions animals to pursue objects and environments for survival. It is possible that such an effect may enhance an adaptive behavior including exploration, and the acquired affective incentive value for cues associated with natural and drug rewards (Imeh-Nathaniel et al, 2016 ).…”

Section: Novel Stimuli Directly Augment Exploration and Appetitive Momentioning

confidence: 99%

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The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

et al. 2017

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The idea that addiction occurs when the brain is not able to differentiate whether specific reward circuits were triggered by adaptive natural rewards or falsely activated by addictive drugs exist in several models of drug addiction. The suitability of crayfish (Orconectes rusticus) for drug addiction research arises from developmental variation of growth, life span, reproduction, behavior and some quantitative traits, especially among isogenic mates reared in the same environment. This broad spectrum of traits makes it easier to analyze the effect of mammalian drugs of abuse in shaping behavioral phenotype. Moreover, the broad behavioral repertoire allows the investigation of self-reinforcing circuitries involving appetitive and exploratory motor behavior, while the step-wise alteration of the phenotype by metamorphosis allows accurate longitudinal analysis of different behavioral states. This paper reviews a series of recent experimental findings that evidence the suitability of crayfish as an invertebrate model system for the study of drug addiction. Results from these studies reveal that unconditioned exposure to mammalian drugs of abuse produces a variety of stereotyped behaviors. Moreover, if presented in the context of novelty, drugs directly stimulate exploration and appetitive motor patterns along with molecular processes for drug conditioned reward. Findings from these studies indicate the existence of drug sensitive circuitry in crayfish that facilitates exploratory behavior and appetitive motor patterns via increased incentive salience of environmental stimuli or by increasing exploratory motor patterns. This work demonstrates the potential of crayfish as a model system for research into the neural mechanisms of addiction, by contributing an evolutionary, comparative context to our understanding of natural reward as an important life-sustaining process.

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Section: Novel Stimuli Directly Augment Exploration and Appetitive Momentioning

confidence: 99%

Section: Novel Stimuli Directly Augment Exploration and Appetitive Momentioning

confidence: 99%

The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

et al. 2017

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“…The psychostimulant effects of invertebrates closely resemble those found in mammals for substituted phenethylamines [Alcaro et al, 2011;Huber et al, 2011;Gore et al, 2020] (i.e., amphetamines and cathinones) or alcohol [Swierzbinski et al, 2017]. Rewarding properties of psychostimulant drugs were confirmed in crayfish conditioned place preference experiments [Imeh-Nathaniel et al, 2016]. Robust bias for the associated sensory environment arose when it was paired with infusions of amphetamine, cocaine, methamphetamine, and opioids [Panksepp and Huber, 2004;Nathaniel et al, 2010;Imeh-Nathaniel et al, 2016].…”

Section: Doi: 101159/000517121mentioning

confidence: 67%

The Phylogenetic Roots of Addiction: Compulsive Drug Seeking, Natural and Drug-Sensitive Reward, and the Acquisition of Learned Habits

Huber

Jacobson

2020

Brain Behav Evol

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“…We explored the reinforcing properties of psychostimulants in crayfish using a series of conditioned place preference (CPP) experiments in which a particular visual or tactile environment was paired with psychostimulant infusions over multiple days. A robust preference for the associated environments emerged as crayfish strongly sought out cues that had previously been paired with the administration of amphetamine or cocaine (Panksepp & Huber, 2004), opioid (Nathaniel et al, 2010), methamphetamine (Imeh-Nathaniel, Adedeji, Huber, & Nathaniel, 2016), or synthetic cathinones (Gore, 2017). When systemic infusion was paired with a distinct visual environment, amphetamine elicited stronger drug-paired conditioning than did cocaine (Panksepp & Huber, 2004).…”

Section: Cue Learning and Rewardmentioning

confidence: 99%

“…Although multiple instances of paired training were necessary to develop the full extent of substrate conditioning, a single drug application was sufficient to enhance cue preference. Crayfish reward is similarly sensitive to methamphetamine (2.5, 5.0, and 10.0 μg/g doses), with animals exhibiting a strong preference for the paired tactile environment following conditioning trials (Imeh-Nathaniel et al, 2016). More recently, we compared the behavioral effects resulting from treatment with select, novel, synthetic cathinones (methylone, mephedrone), to their better known substituted methylmethamphetamine analogs (Gore et al, in review).…”

Section: Cue Learning and Rewardmentioning

confidence: 99%

Crayfish Learning: Addiction and the Ganglionic Brain

Staaden

Huber

2018

Perspect Behav Sci

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Recognizing addiction as a phenomenon with deep evolutionary roots grants valuable new perspectives into understanding its behavioral features, as well as its underlying neural mechanisms and genetic architecture. Although now generally misbranded as "human drugs of abuse," addictive plant alkaloids originally arose as potent chemical defenses against insect herbivory. The products of this evolutionary arms race, compounds such as nicotine, cathinone, or morphine, target essential biological mechanisms for motivation and learning and act as weaponized disruptors. Human vulnerabilities to these addictive drugs may thus represent little more than collateral damage arising from deep homology, i.e., shared biological implementation of behavioral functions with taxa that trace back to the early divergence of bilateral metazoans. Consistent with such a view, invertebrate preparations exhibit a rich spectrum of behavioral and neural consequences in response to drug exposure. Although there is certainly evidence for addiction-like phenomena in many invertebrate lineages, the present review focuses attention primarily on our recent work in crayfish. Using this decapod crustacean model, we have characterized a range of amphetamines, cathinones, and opioids for evidence of unconditioned intoxication, sympathomimetic properties, psychostimulant sensitization, conditioned cue learning, and operant selfadministration. Overall, our findings on drug-sensitive reward in crayfish bear striking similarities to equivalent phenomena illustrated in mammals. Experimentally tractable invertebrate models may thus provide fundamental insights into the homo-and paralogous mechanisms mediating responses to addictive drugs, while illuminating the limits of such contrasts.

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The rewarding properties of methamphetamine in an invertebrate model of drug addiction

Cited by 11 publications

References 22 publications

The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse

The Phylogenetic Roots of Addiction: Compulsive Drug Seeking, Natural and Drug-Sensitive Reward, and the Acquisition of Learned Habits

Crayfish Learning: Addiction and the Ganglionic Brain

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