The reversible effects of free fatty acids on sulfonylurea-stimulated insulin secretion are related to the expression and dynamin-mediated endocytosis of KATP channels in pancreatic β cells
Abstract:Objective: Lipotoxicity-induced pancreatic β cells-dysfunction results in decreased insulin secretion in response to multiple stimulus. In this study, we investigated the reversible effects of palmitate (PA) or oleate (OA) on insulin secretion and the relationship with pancreatic β cell ATP-sensitive potassium (KATP) channels.
Methods: MIN6 cells were treated with PA and OA for 48 hr and then washed out for 24 hr to determine the changes in expression and endocytosis of the KATP channels and insulin secretion… Show more
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