The Reversibility of Glycogen Nephrosis in Alloxan-Treated Diabetic Rats

Robbins, S L

doi:10.1097/00000441-195004000-00003

Cited by 17 publications

(6 citation statements)

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“…The accumulation of glycogen is, therefore, considered the consequence of excessive reabsorption of glucose rather than the expression of cellular degeneration. Indeed, and in agreement with observations made by others [6,41,34,33,11], the extent of glycogenic infiltration observed in our animMs appeared to correlate with the degree of hyperglycemia and glycosuria. A puzzling but unquestioned finding is that of considerable differences in the degree of glycogen infiltration which were observed between individual cells of a given tubular segment though it is likely that neighbouring cells were exposed to the same metabolic environment both on their tissnlar and their luminar surfaces.…”

Section: Discussionsupporting

confidence: 94%

The kidney of spiny mice (Acomys cahirinus): Electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia

et al. 1970

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Section: Discussionsupporting

confidence: 94%

The kidney of spiny mice (Acomys cahirinus): Electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia

et al. 1970

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“…The fact that the cytoplasmic organelles of renal tubules of spontaneous diabetic rats suffering from glycogen nephrosis showed no degenerative findings supports the previous report (Robbins, 1950) that glycogen nephrosis is reversible and not an irreversible degenerative lesion.…”

Section: S Y N Osissupporting

confidence: 90%

“…In alloxan diabetic rats, high blood sugar level over 350mg/dl causes glycogen nephrosis and is a reversible lesion (Robbins, 1950). Among spontaneously diabetic rodents, only the sand rat has shown glycogen nephrosis (Hackel et al 1965).…”

Section: S Y N Osismentioning

confidence: 99%

Electron Microscopic Studies of the Pancreatic Islets and Some Other Organs in Experimental Congenital Diabetic Rats

Yamamoto

1971

Endocrinol Japon

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Nineteen rats were obtained by the mating of two spontaneous diabetic males, that had diabetes for over one month, with three nondiabetic females, all of which were born from alloxan diabetic rats in the same successive generations. General observations on these animals and light and electron microscopic studies on their pancreatic islets as well as some other organs were performed. Among 19 rats, 11 developed diabetes spontaneously without any treatment, 5 of which showed long persistent diabetes.(a) Before the onset of diabetes, the pancreatic B-cells showed hypoplasia (reduced in number and size). Electron microscopically, some B-cells in the granular stage showed degranulation and an increased number of ribosomes, some B-cells in the predominantly agranular stage irregular dilatation of granular endoplasmic reticulum. (b) After the onset of diabetes, some pancreatic B-cells showed hydropic degeneration and vacuolar formation, other B-cells pyknosis and atrophy. Under electron microscopy, marked degranulation, swelling and vacuolation of mitochondria, and a decreased number of ribosomes were observed in all pancreatic B-cells, and in addition, marked irregular dilatation of granular endoplasmic reticulum in the predominantly agranular stage. The adrenal gland showed slight hypertrophy and in the cells of the fascicular zone an increased number of ribosomes and abundant dilated agranular endoplasmic reticula both before and after the onset of diabetes were observed.In the kidney, the glomerulus showed no obvious changes, but the renal tubules demonstrated deposition of glycogen particles in the diabetic stage and they did not show any degenerative lesions in their organelles. In short, in experimental congenital diabetic rats, the pancreatic B-cells work excessively to maintain the animals free of diabetes, during the early prediabetic stage; however, with the aging process their growth disturbance becomes severe, they are exhausted and show degeneration and finally spontaneous diabetes occurs. The presumed hyperfunction of their adrenal cortex accelerates the onset of diabetes.Since Okamoto (1952) found hypoplasia of the pancreatic B-cells in the descendants of alloxan diabetic rabbits, many investigations on these animals have been made, with many interesting results. That is, the diabetic animals (rabbits, rats and guinea pigs) in which diabetes was induced by the administration of alloxan or other diabetogenic substances, were mated after being kept diabetic for more than one month, to obtain F1 offspring and this process was repeated to obtain F2 and several subsequent genrations. On examination it was revealed that these descendants had hypoplasia of the pancreatic B-cells (reduced in number and in size), increased percentage of acidophiles in the adenohypophysis and hypertrophy of the adrenal cortex (especially zona fasciculata). These changes gradually

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“…In addition to the overproduction of saccharide enriched basement membrane several other pathways of enhanced synthesis should be noted. The deposition of glycogen has been observed in the renal tubules of uncontrolled human diabetics [71] and alloxan diabetic rats [72]. In the latter it could be demonstrated that the severity of the glycogen nephrosis reflected the degree of hyperglycemia and could be reversed by lowering of the blood glucose level.…”

Section: Role Of Hyperglycemiamentioning

confidence: 99%

Search for a biochemical basis of diabetic microangiopathy

1976

Diabetologia

191

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Summary. Diabetic microangiopathy, particularly as seen in the renal glomerulus, is characterized by morphological and biochemical alterations of the capillary basement membrane. Observations from a number of disciplines have indicated that the microvascular disease is not a separately inherited entity but a true consequence or "complication" of insulin deficiency. An evaluation of the biochemical events which could be responsible for the basement membrane lesions of diabetes indicates that the hyperglycemia or plasma somatotropin elevation of this disease alone, or in combination, may play an important role.

show abstract

The Reversibility of Glycogen Nephrosis in Alloxan-Treated Diabetic Rats

Cited by 17 publications

References 0 publications

The kidney of spiny mice (Acomys cahirinus): Electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia

The kidney of spiny mice (Acomys cahirinus): Electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia

Electron Microscopic Studies of the Pancreatic Islets and Some Other Organs in Experimental Congenital Diabetic Rats

Search for a biochemical basis of diabetic microangiopathy

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