The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior

Peleh, Tatiana; Ike, Kevin G O; Wams, Emma J.; Lebois, Evan P.; Hengerer, Bastian

doi:10.1016/j.neubiorev.2018.07.018

Cited by 20 publications

(14 citation statements)

References 254 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The visible burrow system of their design was then used at the Blanchard laboratory 57–59 and the Sakai laboratory (for review see References 21,60) and then scaled down to house groups of unfamiliar mice 23,61 . Later it was modified to fit more animals and compartments 22 and allow for automatic scoring of social behaviors with the use of combined video and RFID tag recording 32,62 . The latter approach has been used by other groups to track social interactions of mice in complex open spaces 29,63,64 and in home cage environment 27,65 .…”

Section: Discussionmentioning

confidence: 99%

Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test

Winiarski

Kondrakiewicz

et al. 2022

Genes Brain and Behavior

View full text Add to dashboard Cite

Translational value of mouse models of neuropsychiatric disorders depends heavily on the accuracy with which they replicate symptoms observed in the human population. In mouse models of autism spectrum disorder (ASD) these include, among others, social affiliation, and communication deficits as well as impairments in understanding and perception of others. Most studies addressing these issues in the BTBR T+ Itpr3tf/J mouse, an idiopathic model of ASD, were based on short dyadic interactions of often non‐familiar partners placed in a novel environment. In such stressful and variable conditions, the reproducibility of the phenotype was low. Here, we compared physical conditions and the degree of habituation of mice at the time of testing in the three chambered social affiliation task, as well as parameters used to measure social deficits and found that both the level of stress and human bias profoundly affect the results of the test. To minimize these effects, we tested social preference and network dynamics in mice group‐housed in the Eco‐HAB system. This automated recording allowed for long‐lasting monitoring of differences in social repertoire (including interest in social stimuli) in BTBR T+ Itpr3tf/J and normosocial c57BL/6J mice. With these observations we further validate the BTBR T+ Itpr3tf/J mouse as a model for ASD, but at the same time emphasize the need for more ecological testing of social behavior within all constructs of the Systems for Social Processes domain (as defined by the Research Domain Criteria framework).

show abstract

Section: Discussionmentioning

confidence: 99%

Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test

Winiarski

Kondrakiewicz

et al. 2022

Genes Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…Further, the vast majority of research in the VBS has focused on stress responsivity and metabolic phenotypes, and much more research is needed to more fully understand the nature of those immunological, cardiovascular, and neural outcomes that are impacted by VBS social stress. However, with the advent of video capture methods capable of tracking multiple animals in large arenas, as well as minimally invasive wireless methods for the long-term capture of physiological data, it is likely that there will be increased interest in these questions (Peleh et al, 2019;Plank et al, 2016;Redfern et al, 2017). Another area of research that is relatively little understood is how social stress impacts the formation of social hierarchies in the VBS, although studies in dyads suggest that stress may actually facilitate dominance-subordinate status in rat dyads (Cordero and Sandi, 2007;Timmer et al, 2011; see also section 3.3 in voles).…”

Section: Discussionmentioning

confidence: 99%

Stress in groups: Lessons from non-traditional rodent species and housing models

Beery

Holmes

Lee

et al. 2020

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

A major feature of life in groups is that individuals experience social stressors of varying intensity and type. Social stress can have profound effects on health, social behavior, and ongoing relationships. Relationships can also buffer the experience of exogenous stressors. Social stress has most commonly been investigated in dyadic contexts in mice and rats that produce intense stress. Here we review findings from studies of diverse rodents and non-traditional group housing paradigms, focusing on laboratory studies of mice and rats housed in visible burrow systems, prairie and meadow voles, and mole-rats. We argue that the use of methods informed by the natural ecology of rodent species provides novel insights into the relationship between social stress, behavior and physiology. In particular, we describe how this ethologically inspired approach reveals how individuals vary in their experience of and response to social stress, and how ecological and social contexts impact the effects of stress. Social stress induces adaptive changes, as well as long-term disruptive effects on behavior and physiology.

show abstract

“…The similarity is apparent in design features and components within the product. Peleh et al (2019) define standardization as treating the use of common parts as essential to a modular poultry product production design.…”

Section: Integrator Involvement In Poultry Product Modularitymentioning

confidence: 99%

Measuring the performance of poultry business through effective supply chain management skills

Ronaldo¹

2020

10.5267/j.uscm

View full text Add to dashboard Cite

The reverse translation of a quantitative neuropsychiatric framework into preclinical studies: Focus on social interaction and behavior

Cited by 20 publications

References 254 publications

Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test

Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test

Stress in groups: Lessons from non-traditional rodent species and housing models

Measuring the performance of poultry business through effective supply chain management skills

Contact Info

Product

Resources

About