The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells

Take a deep breath and digest the material: organoids and biomaterials of the respiratory and digestive systems

“…[71,72] Reports are beginning to emerge with the transplantation of hPSC-derived immature beta cells on microporous PLGA and PLLA scaffolds, but thus far have only reported some beta cell maturation in vivo and a short rescue of normoglycemia in diabetic mice. [70,73,74] Acinar and ductal organoids…”

Encapsulation technologies in beta cell replacement therapies for Type 1 diabetes

“…Several novel strategies to ameliorate hypoxia in encapsulated cells including the use of oxygen-generating chemicals [polydimethylsiloxane (PDMS)--encapsulated solid calcium peroxide] [151], co-encapsulation with photosynthetically-active microorganisms (Synechococcus lividus) [152] and implantable devices fitted with access ports to enable direct O2 delivery -the β-Air device [153] -are all being evaluated.…”

Tissue Engineering for Tissue and Organ Regeneration

“…Scaffolds should provide an initial support for the islet grafts during the early post transplant period, enabling the development of a capillary bed and recovery of extracellular matrix interactions (Stock & Vacanti, 2009). Polymers such as polylactic acid, polyglycolic acid, polylactide-copolyglycolide (PLGA) (Mao et al, 2009), polyvinyl alcohol -polycaprolactone (Mohan et al, 2010) were extensively used for scaffold fabrication purpose for the tissue engineering of various tissues.…”