The retrospective analysis results of the endometrial tissue pathological conditions development

Artyomenko, Volodymyr; Chumak, Z. V.; Shapoval, M. V.

doi:10.18370/2309-4117.2020.55.48-52

Cited by 3 publications

(2 citation statements)

References 17 publications

(26 reference statements)

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“…Згідно із сучасними уявленнями, супутні захворювання, що спричинені ожирінням, пов'язані не тільки з кардіометаболічною дисфункцією, цукровим діабетом 2-го типу (ЦД-2), артеріальною гіпертензією та іншими ознаками метаболічного синдрому, а й із синдромом полікістозних яєчників (СПКЯ). Ба більше, доброякісні та злоякісні новоутворення матки, яєчників і ендометрію часто є коморбідними ожирінню [4,27].…”

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New approaches to early detection of polycystic ovary syndrome in obese women

Artyomenko

Velychko²,

Lahoda

2022

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Objectives: development of an algorithm for the early detection of comorbid pathology polycystic ovary syndrome (PCOS) in obese women.Materials and methods. The study included 56 women aged 28.02 ± 2.25 years with a diagnosis of obesity who had no history of PCOS. The examination was carried out by a multidisciplinary group of doctors consisting of a family doctor, a gynecologist and an endocrinologist.The patient’s history of life and diseases was studied, an anthropometric еxamination and a survey according to the modified Ferriman–Gallwey scale were performed with a further ultrasound examination and a gynecologist consultation.Results. The majority of patients (55.36%) had acne, hirsutism and seborrhea occurred in 41.07 and 26.76% of women, respectively, and 14.29% of patients had alopecia. Often, the patient had not one, but several symptoms at the same time.According to the modified Ferriman–Gallwey scale, the majority of women (58.92%) had no manifestations of hirsutism along with obesity, 17.8% had moderate manifestations of hirsutism, 16.07 and 7.14% had mild and moderate hirsutism, respectively.The patients had no complaints and did not know whether they had PCOS. PCOS were diagnosed in 31 (55.36%) women after ultrasound examination and gynecologist consultation. It was also found that patients with longer obesity and a higher body mass index were more likely to have a diagnosis of PCOS (ρ = 0.77). The largest number of PCOS patients was among women with a body mass index over 40 kg/m2, i.e. with the III degree of obesity.Conclusions. The algorithm we developed for the diagnosis of PCOS in obese patients allowed us to detect this disease early in 55.36% of cases. We consider it appropriate to recommend screening for PCOS to all obese patients of reproductive age. This tactic will help maintain the fertility of this category of patients.

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New approaches to early detection of polycystic ovary syndrome in obese women

Artyomenko

Velychko²,

Lahoda

2022

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“…Women with PCOS have a high prevalence of metabolic syndrome, with rates reaching up to 33%. MS is linked to long-term consequences such as cardiovascular diseases, type 2 diabetes mellitus (T2DM) cancer, sleep apnea, and psychological issues [2].…”

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confidence: 99%

Common clinical laboratory features among women with polycystic ovary syndrome and metabolic syndrome

Lahoda,

Artyomenko,

Velychko

et al. 2023

JMedLife

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Women with polycystic ovary syndrome (PCOS) have a high prevalence of metabolic syndrome (MS), with rates up to 33%. This is associated with long-term consequences such as cardiovascular diseases, type 2 diabetes mellitus (T2DM), cancer, sleep apnea, and psychological issues. The prevalence of MS worldwide is often associated with obesity and T2DM, yet regional variations are reported. In this study, 122 women consulting general practice and family medicine physicians were evaluated, revealing a BMI exceeding 30 kg/m². Among MS criteria, the most common diagnoses were T2DM in 29 patients, insulin resistance (IR) in 36, arterial hypertension (AH) in 51, reduced HDL levels in 53, and elevated triglycerides in 39. Further analysis revealed 16 unique combinations of MS components in these patients, with 75% of PCOS cases exhibiting three MS components and 25% having four. Additionally, research indicated that most women with PCOS face persistent, treatment-resistant obesity, with a notably higher BMI (ρ=0.87; r=0.76). These findings highlight the multifactorial nature of PCOS and MS etiology.

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Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women

et al. 2023

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Hyperplastic processes of the endometrium (HPE) are a group of benign endometrial and stromal cells that have undergone altered growth. This study aimed to investigate the potential role of hypoxia (as indicated by Hif-1α) and apoptosis markers (p53 and BCL-2) in the development of hyperplastic processes of the endometrium (HPE). Results showed that endometrial cells with atypical hyperplasia had increased levels of Hif-1ɑ, which indicates the presence of endometrial hypoxia and may trigger pathological manifestations. Though this result was not statistically significant, it could be the cause of atypia hyperplasia in the late reproductive period (Hif-1ɑ=1.89±0.09 units) and the perimenopausal period (Hif-1ɑ=2.09±0.07 units). Additionally, the study found that p53 markers were elevated in epithelial cells in the late reproductive period, and similar patterns were observed in the perimenopausal period, with the biggest expression in atypical hyperplasia. The study also found that the high expression of BCL-2 indicator (+++) was less common in late reproductive period women with atypia than those without it (χ2=7.2 p=0.01). A similar situation was observed in women in the perimenopausal period (χ2=4.2 p=0.04). These findings suggest that hypoxia may play a role in the development of HPE, as well as changes in apoptotic markers present in the endometrial tissue.

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The retrospective analysis results of the endometrial tissue pathological conditions development

Cited by 3 publications

References 17 publications

New approaches to early detection of polycystic ovary syndrome in obese women

New approaches to early detection of polycystic ovary syndrome in obese women

Common clinical laboratory features among women with polycystic ovary syndrome and metabolic syndrome

Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women

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