The retinal nerve fiber layer, neuroretinal rim area, and visual evoked potentials in MS

MacFadyen, D.J.; Drance, S M; Douglas, Gordon R.; Airaksinen, P. Juhani; Mawson, Daniel K.; Paty, D. W.

doi:10.1212/wnl.38.9.1353

Cited by 40 publications

(35 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Abnormalities in the RNFL of patients with MS were first described by Frisen & Hoyt (1974), using achromatic photographs, and were later confirmed in other studies (MacFadyen et al 1988;Elbol & Work 1990). Since then, the development of digital imaging technology has provided some useful tools to measure and quantify RNFL defects in these patients.…”

Section: Discussionmentioning

confidence: 81%

Sub‐clinical atrophy of the retinal nerve fibre layer in multiple sclerosis

Pueyo

Ara

Almárcegui

et al. 2009

Acta Ophthalmologica

View full text Add to dashboard Cite

Acta Ophthalmol. 2010: 88: 748–752 Abstract. Purpose: This study aimed to evaluate the presence of abnormalities in the retinal nerve fibre layer (RNFL) in multiple sclerosis (MS) patients with normal ophthalmic examination, and to compare the ability of optical coherence tomography (OCT) and scanning laser polarimetry (GDx) to detect axonal loss. Methods: Patients with MS and disease‐free controls were invited to enrol in the study from 1 February 2007 to 30 June 2008. Ophthalmic examination, including evaluation of visual acuity (VA) and visual field (VF), showed normal results in all subjects. Retinal nerve fibre layer properties were measured by means of OCT and GDx. Visual evoked potentials (VEPs) were also recorded. Results: Forty eyes of 40 MS patients and 20 eyes of age‐ and sex‐matched controls were included in the study. Despite normal VA and VF results, significant differences between the two groups were observed in VF mean deviation (MD), most of the RNFL measurements provided by OCT and GDx, and VEP P100 latency and amplitude. There was a significant correlation between OCT and GDx parameters, and between these parameters and VEP results. Nineteen MS eyes (35.7%) showed RNFL abnormalities detected either by OCT or GDx. Discussion: Sub‐clinical ganglion cell loss can be detected in MS patients with normal visual function. Both OCT and GDx are useful complementary tools with which to identify this damage.

show abstract

Section: Discussionmentioning

confidence: 81%

Sub‐clinical atrophy of the retinal nerve fibre layer in multiple sclerosis

Pueyo

Ara

Almárcegui

et al. 2009

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…29 In MS patients, RNFL abnormalities have been found in up to 80% of the cases by inspection of red-free retinal photographs. 30,31 Also, optic disc pallor detected by direct ophthalmoscopy or by slides has been described in up to 71% of eyes previously affected by ON. 31,32 However, clinical assessment using these techniques is somewhat subjective, prone to interobserver variability, and does not produce quantitative data.…”

Section: Discussionmentioning

confidence: 99%

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Iester

Cioli

Uccelli

et al. 2007

Eye

View full text Add to dashboard Cite

Purpose To verify whether scanning laser polarimeter with the new variable corneal compensation algorithm (GDx VCC) and scanning laser ophthalmoscopy (Heidelberg Retina Tomograph (HRT)) allow measuring retinal ganglion cell loss in patients with multiple sclerosis (MS). Patients and methods We enrolled 23 MS patients with a history of previous demyelinating monocular optic neuritis. Examination included visual evoked potentials (VEPs), scanning laser ophthalmoscopy, and scanning laser polarimeter. HRT was performed to assess optic nerve head (ONH) shape, while GDx VCC was used to evaluate the retinal nerve fibre layer thickness (RNFLt) around the ONH. Statistical analysis was performed comparing results obtained for each eye with the available normative database and with the unaffected fellow eye. Results When the affected eye group was compared to the fellow-eye group, a significant (Po0.05) difference was found for few GDx VCC parameters. In contrast, no significant correlation was observed between clinical assessment and imaging techniques when the normal database of HRT and GDx VCC was used. A significant association was observed between VEP latency and some GDx VCC parameters. Conclusions Our results suggested that scanning laser polarimetry could detect loss of ganglion cells following demyelinating optic neuritis, but further studies are needed.

show abstract

“…Optic neuritis is the most common inflammatory optic neuropathy in young adults Rizzo & Lessell, 1988). Demyelination itself does not immediately cause loss of retinal ganglion cells; many rounds of inflammation and demylination eventually lead to axon loss (Evangelou et al, 2000;Perry & Anthony, 1999;Trapp et al, 1998), which again clinically appears as optic atrophy and loss of the nerve fiber layer (MacFadyen et al, 1988). What mechanisms induce retinal ganglion cell death in glaucoma and other optic neuropathies?…”

Section: Pathologymentioning

confidence: 99%