The Retinal Nerve Fiber Layer in Normal Eyes

Jonas, Jost B.; Nguyen, Nhung X.; Naumann, Gottfried O.H.

doi:10.1016/s0161-6420(89)32838-7

Cited by 138 publications

(90 citation statements)

References 25 publications

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“…The loss of retinal ganglion cells (RGCs) is a consistent feature of the ageing mammalian visual system, which is thought to contribute to the age-related decline in visual function (Sanchez et al, 1986;Jonas et al, 1989;Jonas et al, 1990;Morrison et al, 1990;Harman et al, 2000;Neufeld and Gachie, 2003). The role of apoptosis in the elimination of RGCs in ageing and retinal pathology has been well documented (Spear, 1993;Quigley et al, 1995;Cecconi et al, 1998;Neufeld and Gachie, 2003).…”

Section: Introductionmentioning

confidence: 99%

Cellular inhibitor of apoptosis (cIAP1) is down-regulated during Retinal ganglion cell (RGC) maturation

Kisiswa

Albon

Morgan

et al. 2010

Experimental Eye Research

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Please cite this article as: Kisiswa, L., Albon, J., Morgan, J.E., Wride, M.A. Cellular inhibitor of apoptosis (cIAP1) is down-regulated during Retinal ganglion cell (RGC) maturation, Experimental Eye Research (2010Research ( ), doi: 10.1016Research ( /j.exer.2010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. This work was supported by National Eye Research Centre (NERC), UK, Grant RCOP256. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 AbstractApoptosis, is the main type of cell death that occurs in ageing and neurodegenerative disease, such as glaucoma. This study therefore characterises the expression profile of caspases (proapoptosis) and inhibitors of apoptosis (IAPs; anti-apoptosis) during maturation of the BrownNorway rat retina between 6 weeks and >24 weeks and also examines concomitant changes in expression of tumor necrosis factor receptor associated factor 2 (TRAF2). The expression profiles of caspases (initiator caspases 8, 9 and effector caspases 6, 7, 3) and inhibitors of apoptosis (IAPs) (Neuronal IAP), cellular IAP1 and 2 (cIAP1/2), X-chromosome linked IAP (XIAP), Survivin, Bruce and Livin) were examined in retinae from 6 weeks and >24 weeks old BN rats using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR, Western blotting and immunofluoroscence analysis. Caspase expression was not altered significantly during the study interval. IAP expression showed a general reduction during maturation of BN retina, which was statistically significant for cIAP1. cIAP1 reduction was confirmed by Western blotting and immunoflouroscence and was restricted to cells in the retinal ganglion cell layer (RGCL). Accumulation of TRAF2 was observed in the RGCL accompanying the down-regulation of cIAP1 observed. Our results suggest that cells in the mature RGCL may have a greater susceptibility to cell death compared to their younger counterparts and this may be due in part to a reduction in activation of survival pathways involving IAPs and TRAFs.

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Section: Introductionmentioning

confidence: 99%

Cellular inhibitor of apoptosis (cIAP1) is down-regulated during Retinal ganglion cell (RGC) maturation

Kisiswa

Albon

Morgan

et al. 2010

Experimental Eye Research

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“…In most healthy patients, the foveal center lie temporal to and just inferior to the vertical center of the optic nerve [1] . The fovea lies 0.5 mm inferior to a line drawn horizontally through the center of the disc.…”

Section: Discussionmentioning

confidence: 97%

“…The fovea lies 0.5 mm inferior to a line drawn horizontally through the center of the disc. Foveal ectopia occurs in various congenital and acquired conditions, including trauma, chorioretinitis, optic nerve coloboma, retinopathy of prematurity, developmental causes, familial exudative vitreoretinopathy, Norrie's disease, incontinentia pigmenti, and combined hamartoma of the retina and retinal pigment epithelium [1,2] . In our patient, temporal and superior misalignment of the fovea was seen in her right eye.…”

Section: Discussionmentioning

confidence: 99%

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Foveal Pseudoectopıa: Report of A Case and Review of the Literature

Beyazyıldız

Çıtırık

2016

International Journal of Ophthalmic Research

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“…However, ophthalmoscopic examination of the RNFL is notoriously difficult, and only yields qualitative results. Grading scales have been described, 41,42 but are infrequently used in the clinical setting. Photography of this structure is possible, but is often limited by the presence of media opacities.…”

Section: Assessment Of the Optic Nerve Head And Retinal Nerve Fibre Lmentioning

confidence: 99%

The effectiveness of the Heidelberg Retina Tomograph and laser diagnostic glaucoma scanning system (GDx) in detecting and monitoring glaucoma

Kwartz

Henson²,

Harper³

et al. 2005

Health Technol Assess

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The Retinal Nerve Fiber Layer in Normal Eyes

Cited by 138 publications

References 25 publications

Cellular inhibitor of apoptosis (cIAP1) is down-regulated during Retinal ganglion cell (RGC) maturation

Cellular inhibitor of apoptosis (cIAP1) is down-regulated during Retinal ganglion cell (RGC) maturation

Foveal Pseudoectopıa: Report of A Case and Review of the Literature

The effectiveness of the Heidelberg Retina Tomograph and laser diagnostic glaucoma scanning system (GDx) in detecting and monitoring glaucoma

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