The Reticuloendotheliosis Viruses

Lymphoreticular tumour in pen‐raised pheasants associated with a reticuloendotheliosis like virus infection

“…Almost all isolates caused a similar distinct early CPE in both CEF and DEF, which disappeared completely during further incubation. A similar phenomenon has been described by Temin and Kassner (1974;1975) for the REV-T strain. Syncytium formation, a characteristic feature of some other REV isolates, was common, particularly in DEF (for review, see Purchase and Witter, 1975).…”

“…A similar phenomenon has been described by Temin and Kassner (1974;1975) for the REV-T strain. Syncytium formation, a characteristic feature of some other REV isolates, was common, particularly in DEF (for review, see Purchase and Witter, 1975). The ultrastructure of our pheasant REV isolates was indistinguishable from that of other REVs.…”

Lymphoproliferative disease of turkeys: Pathogenesis, Viraemia and serum protein analysis following infection1

“…This change was not present in turkey poults experimentally infected with LPDV. RE-infected chicks are anaemic, and are defective in their immune response (Howard etal., 1967;Purchase and Witter, 1975;Biilow, 1977;Scofield and Bose, 1978;Ianconescu and Aharonovici, 1978). The hypergammaglobulinaemia reported here in LPDV-infected turkeys was apparently polyclonal.…”

“…Marek's disease, which is caused by a herpesvirus, is a lymphomatous disease of T-cell origin (Sharma et al, 1977), while in chicken lymphoid leukosis, which is caused by a type C retrovirus, the tumour cells is a B-cell (Purchase and Burmester, 1975). Reticuloendotheliosis (RE), another neoplastic disease of chickens, turkeys and other birds induced by a type-C retrovirus (Theilen et al, 1966;Purchase and Witter, 1975) is also accompanied by an elevation in serum 7-globulin concentration. However, in RE this was shown to be due to a marked increase in transferrin (which has electrophoretic mobility similar to ß-and 7-globulins) (Torres-Medina et al, 1973).…”

Characterization of T-cell lymphomas associated with an outbreak of reticuloendotheliosis in turkeys

“…It is immunologicall y, morphologically, and structurally distinct from the leukemia/sarcoma group (Purchase & Witter, 1975). REV can cause acute reticular cell neoplasia, chronic neoplasia of lymphoid tissues and other organs, and runting disease syndrome (Witter, 1997).…”