The retention of metabolic radioactive carbonate

Exchange of carbon dioxide in the pregnant rhesus monkey: multicompartmental analysis of carbon dioxide kinetics

“…This appears to be justified because under relatively constant conditions the rate of COa fixation by either the fetal or maternal tissue would be insignificantly low compared to the rate of COs production. Judging from the findings that the metabolic rate based upon the rate of CO, production by the fetal monkey in our study is similar to that based upon O2 consumption by the newborn monkey found by Dawes et al which was measured quite accurately because of the technical feasibility in the newborn animal, and that all the fetuses in our study survived with normal heart rates for [5][6][7][8][9][10][11][12][13][14] days after the experiment, we believe that the condition of our fetuses was within the physiological limit. How Since we know all compartments exchange with each other, we set up the model as the following one,…”

The excretion of 14CO2 during the continuous intravenous infusion of NaH14CO3 in unanaesthetized rats

“…In a mathematical treatment of Kornberg's data for 14CO2 excretion in cats, Steele (1955) proposed a model comprising a central plasma pool and two peripheral pools which he designated 'soft tissue' and 'bone'. He showed that if 14CO2 arising from the oxidation of a labelled substrate was released continuously as bicarbonate into one or other of the peripheral pools, the excretion pattern of 14CO2 would be different from that obtained by continuously infusing NaH14CO3 into the circulation.…”

“…This is due to the multiplicity of metabolic events concerned in the conversion of a metabolite to C02, and in the subsequent transport and elimination of this CO2 from the body. The complexities of the processes involved in the excretion of C02 have been investigated (Kornberg, Davies & Wood, 1952; Steele, 1955;Robinson & Coxon, 1957; Shipley, Baker, Incefy & Clark, 1959; Coxon & Robinson, 1959a) and these data have been used in the interpretation of experiments in which the oxidation of various labelled compounds injected intravenously was studied (Baker, Shipley, Clark, Incefy & Skinner, 1961;Coxon & Robinson, 1959b; Steele, Altszuler, Wall, Dunn & de Bodo, 1959).…”

STUDIES OF THE VENTILATION-PERFUSION RELATIONSHIPS IN THE LUNGS OF SUBJECTS WITH CHRONIC PULMONARY EMPHYSEMA, FOLLOWING A SINGLE INTRAVENOUS INJECTION OF RADIOACTIVE KRYPTON (Kr85). I. PRESENTATION AND VALIDATION OF A THEORETICAL MODEL *

“…As the slug of dissolved Kr85 passes through the pulmonary capillaries almost all of it diffuses into the alveolar gas spaces because of the relative insolubility of krypton (8 and the tissue space (T). Three-compartment systems, both closed (10,11) and open (12)(13)(14), have previously been described; the algebraic treatment is therefore abbreviated here. It is noteworthy that in the present model direct access is limited to one compartment (T).…”

“…Mixed expired gas is mixed expired alveolar gas diluted by the admixture of dead space ventilation. Therefore, the mixed expired krypton concentration is: FE = FA!Ṽ T+T2+~ [12] VI + V2 + VD C2 where V1 + V2 + VD = VE. VD is constant in any study and must be determined by other methods (18 in one numerical example (no.…”