The Results of Trabeculectomy with and without Mitomycin C in Young Patients

Abstract

The results of primary trabeculectomy with and without mitomycin C (MMC) were evaluated in young glaucoma patients. The patients, 15–40 years of age, were divided into two main groups and two subgroups. In group IA, primary Cairns type trabeculectomy was performed in 24 eyes of 24 patients with juvenile glaucoma; in group IB, trabeculectomy + MMC 0.4 mg/ml in 3 min was done in 20 eyes of 20 patients with juvenile glaucoma; in group IIA, primary trabeculectomy was performed in 20 eyes of 20 patients with developmental glaucoma, and in group IIB, trabeculectomy + MMC 0.4 mg/ml in 3 min was performed in 16 eyes of 16 patients with developmental glaucoma. The success rate of the surgery was 75% in group IA, 90% in group IB, 50% in group IIA, and 75% in group IIB. There was no statistically significant difference among the groups in terms of success rates of trabeculectomies (p > 0.05).

Comparison between Results of Trabeculectomy in Primary Congenital Glaucoma with and without the Use of Mitomycin C

“…However, most of those reports are based in heterogeneous groups of patients. [2][3][4][5][6][7][8][11][12][16][17][18] Fulcher et al 1 studied patients with PCG for 5 years after TREC had been performed, without the use of MMC, and reported a long survival of the procedure, results similar to that of our study.…”

“…[1][2][3]5 With the use of anti-fibrotic agents, the success of TREC in children has been demonstrated to increase in different studies. 13,17,18 In the present study, as previously reported by Yalvac et al 4 , there was no difference in the outcome of TREC between groups with and without the use of MMC. In our study, such difference was not demonstrated both for a more (IOP Յ 15 mm Hg) and less (IOP < 21 mm Hg) rigorous criterion of failure intraocular pressure.…”

“…7,9,[12][13][14][15][16] These drugs, among which Mitomycin C (MMC) and 5-fluouracil are included, act by reducing wound healing, and are related to a better surgical outcome after TREC both in children [5][6][7][8] and adults. 1,4,[14][15]19 However, a higher incidence of postoperative complications has been reported following frequent use of these agents. 13,[18][19][20] The purpose of the present study was evaluate and compare the outcome of TREC between patients with and without the use of mitomycin C in patients who underwent glaucoma surgery Glaucoma Division of UNIFESP.…”

Success of trabeculotomy in patients with congenital glaucoma operated on within 3 months of birth

“…There have been few reports on the use of Mitomycin-C (MMC) during trabeculectomy in childhood glaucoma. [12][13][14][15][16] Despite achieving good results with the use of MMC, it is not recommendable its use in children with early postnatal period because long-term results and complications of MMC use are not yet known.…”

Effects of thick Tenon's capsule on primary trabeculectomy with mitomycin‐C

“…As with high risk cases, adults younger than 40 years have a more active and thicker Tenon's layer (Gressel et al 1984). Thus, the use of MMC during primary trabeculectomy of young patients may also be favorable (Gressel et al 1984; Jacobi et al 1998; Yalvac et al 1998). However, there are still severe and potentially blinding complications, including thin‐walled and avascular bleb (Kitazawa et al 1993; Susanna et al 2001), hypotony (Zacharia et al 1993; Scott et al 1998), and wound leakage and infection (Parrish & Minckler 1996; Greenfield et al 1996; Lehmann et al 2000) when MMC is used routinely in primary trabeculectomy.…”