The results of the use of thrombolytic therapy in acute myocardial infarction at the prehospital and hospital stage

Abstract

The aim of the study was study of the use of thrombolytic therapy (TLT) in patients with myocardial infarction (MI) with ST segment elevationat the prehospital and hospital stage. The study included 181 patients with ST elevation MI. Depending on the thrombolytic used, the patients were divided into two groups: patients treated with streptokinase were included in the 1st group (n=78); the 2nd group (n=51) included patients with MI with ST segment elevation, who did not undergo TLT due to late seeking medical help or the presence of contraindications. TLT was performed both at the prehospital stage and in a hospital setting. We analyzed the time before TLT, the clinical course of MI, mortality, and complications. The time from the onset of clinical symptoms was 2.70.22 hours. The high efficiency of these thrombolytics was established in 66% of patients. Mortality during TLT was 6.4–7.7%, without TLT - 24%. Carrying out TLT in the first 3 hours from the onset of a heart attack was accompanied by a decrease in mortality to 3.4%. Not a single case of intracranial hemorrhage and allergic reactions was recorded.± TLT with streptokinase in patients with MI with ST segment elevation on the ECG in real clinical practice was characterized by high efficiency, a decrease in hospital mortality, complications, and a low percentage of side effects.