The results of surgery under general anesthesia in patients with lung cancer

Suemitsu, Ryuichi; Takeo, Sadanori; Hamatake, Motoharu; Morokuma, Akiko; Suemori, Yasuhiko; Tanaka, Hiroyuki

doi:10.1007/s00595-009-4215-2

Cited by 7 publications

(7 citation statements)

References 15 publications

(15 reference statements)

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“…MMP-9 is a proteolytic enzyme that activates inflammatory mediators and cells in the lung and increases the permeability of pulmonary capillaries, which leads to pneumonedema (14). The total score of MMSE is 30 points and less than 23 points are regarded as cognitive dysfunction (15). Propofol is the most widely used intravenous anesthesia in clinical surgical treatment and has the function of antioxidation and inhibition of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of sevoflurane and propofol anesthesia on pulmonary function, MMP‑9 and postoperative cognition in patients receiving lung cancer resection

et al. 2019

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Effects of sevoflurane and propofol anesthesia on pulmonary function, matrix metalloproteinase-9 (MMP-9) and postoperative cognition were compared in patients undergoing simple resection of lower lobe of left lung. Retrospective method was used to analyze 58 cases of lung cancer patients treated by simple resection of lower lobe of left lung in the Second Hospital of Dalian Medical University from October 2016 to October 2017, and they were divided into two groups: Sevoflurane group (n=32) with sevoflurane anesthesia and propofol group (n=26) with propofol anesthesia. In the present study, the moment before induction of anesthesia (T1), before the start of one-lung ventilation (T2), before the end of one-lung ventilation (T3), after closed chest surgery (T4), 24 h after surgery (T5), calculate alveolar-arterial oxygen difference (A-aDO2), respiratory index (RI) and intrapulmonary shunt ratio (Qs/Qt), were compared between the two groups. The serum MMP-9 concentration at T1, T4 and T5 were detected by enzyme linked immunosorbent assay. The cognitive function of two groups was assessed by Mini-Mental State Examination (MMSE) 1 day before surgery and 1 and 10 days after surgery. The A-aDO2 level at T4 in sevoflurane group was significantly higher than that in propofol group (P<0.05). The RI level at T3, T4, the Qs/Qt and the MMP-9 level at T4 in the sevoflurane group was significantly higher than that in the propofol group (P<0.05). The MMSE score in sevoflurane group was significantly lower than that in propofol group 1 and 10 days after surgery (P<0.05). Propofol has little effect on pulmonary function and can decrease inflammatory factor MMP-9. Both sevoflurane and propofol have an effect on cognitive function after lung cancer resection, but propofol can reduce cognitive impairment in patients with lung cancer.

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Section: Discussionmentioning

confidence: 99%

Comparison of the effects of sevoflurane and propofol anesthesia on pulmonary function, MMP‑9 and postoperative cognition in patients receiving lung cancer resection

et al. 2019

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“…Our data demonstrated that the risk of PPCs in patients with BMI ≥24.0 kg/m 2 was higher than in patients with BMI <24.0 kg/m 2 (OR 1.514, 95% CI 1.057–2.167, P =0.024) (Table 4). Obese patients often have reduced lung volume, altered ventilation pattern, and comorbid conditions, which are risk factors for intra-and postoperative complications 13,14. Being overweight is an important influencing factor on pre- and postoperative immune function 15.…”

Section: Discussionmentioning

confidence: 99%

<p>Risk factors of postoperative pulmonary complications after minimally invasive anatomic resection for lung cancer</p>

Yang¹,

Wu²,

Yao³

et al. 2019

TCRM

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PurposeThis study investigated the perioperative risk factors of postoperative pulmonary complications (PPCs) after minimally invasive anatomic resection for lung cancer.Patients and methodsWe retrospectively reviewed the data from medical records of 729 lung cancer patients undergoing minimally invasive anatomic lung resections between January 2017 and December 2017. Univariate and binary logistic regression analyses were performed to select the independent risk factors for PPCs during the patient’s postoperative hospitalization after surgery.ResultsThe incidence of PPCs was 24.8% (n=181/729). No patient died during the period of hospitalization. Logistic regression analysis revealed that body mass index (BMI) ≥24.0 kg/m2 (vs <24.0 kg/m2: OR 1.514, 95% CI 1.057–2.167, P=0.024), single segmentectomy (vs single lobectomy: OR 2.115, 95% CI 1.150–3.891, P=0.016), bilobectomy or combined lobectomy and segmentectomy (vs single lobectomy: OR 2.731, 95% CI 1.013–7.361, P=0.047), and right lung lobe surgery (vs left lung lobe surgery: OR 1.519, 95% CI 1.046–2.205, P=0.028) were independent risk factors for PPCs in lung cancer patients who received minimally invasive anatomic lung resections.ConclusionIndividual factors such as BMI ≥24.0 kg/m2, single segmentectomy, bilobectomy or combined lobectomy and segmentectomy, and right lung lobe surgery were independent risk factors of PPCs, which should be helpful for risk stratification, patient counseling, and perioperative care for lung cancer patients.

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“…Durante a avaliação pré-operatória desses pacientes, é recomendada a busca de sinais e sintomas de comprometimento pulmonar, pois complicações pulmonares pós-operatórias são bastante frequentes 250 . A exposição prévia a alguns quimioterápicos ou à radioterapia são fatores de risco para complicações pulmonares perioperatórias 250 .…”

Section: -Avaliação Respiratória Do Paciente Oncológicounclassified

“…A exposição prévia a alguns quimioterápicos ou à radioterapia são fatores de risco para complicações pulmonares perioperatórias 250 . A avaliação clínica incluindo anamnese e exame físico é fundamental na identificação de distúrbios do sistema respiratório.…”

Section: -Avaliação Respiratória Do Paciente Oncológicounclassified

I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia

Filho¹,

Hajjar²,

Bacal³

et al. 2011

Arq. Bras. Cardiol.

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The results of surgery under general anesthesia in patients with lung cancer

Abstract: Extremely underweight patients as well as obese patients had a high risk of perioperative complications, especially postoperative thoracic complications. Extremely underweight patients should therefore be carefully observed with regard to respiratory management.

Cited by 7 publications

References 15 publications

Comparison of the effects of sevoflurane and propofol anesthesia on pulmonary function, MMP‑9 and postoperative cognition in patients receiving lung cancer resection

Comparison of the effects of sevoflurane and propofol anesthesia on pulmonary function, MMP‑9 and postoperative cognition in patients receiving lung cancer resection

<p>Risk factors of postoperative pulmonary complications after minimally invasive anatomic resection for lung cancer</p>

I Diretriz Brasileira de Cardio-Oncologia da Sociedade Brasileira de Cardiologia

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