The Results of Nation-Wide Registry of Age-related Macular Degeneration in Korea

Park

Japan Journal Nursing Sci

2019

This study was conducted to identify the prevalence and factors associated with age-related macular degeneration (AMD) in Korean elderly. Methods: The study population of this cross-sectional survey was the Korean Health and Nutrition Examination Survey (KHANES) 2010 through 2012, the fifth population-based study. Results: Analysis of 2,767 elderly (above age 65) from 23,376 participants showed the prevalence of any AMD to be 17.6% in the Korean elderly. Factors that were significantly positively associated with AMD included age, sex, occupation, low socioeconomic status, liver cirrhosis and physical activity (p < .01). Significantly negatively associated with AMD were cardiovascular disease, obesity, and betacarotene intake (p < .05). Conclusions: This study estimated the prevalence rate and assessed factors associated with AMD in the elderly. This can be used to build a strategy for elderly eye health, and provides valuable information for screening for putative risks in the elderly.

Section: Introductionmentioning

confidence: 99%

Age‐related macular degeneration among the elderly: The 5th National Health and Nutrition Examination Survey, 2010 through 2012

Park

Japan Journal Nursing Sci

2019

“…[ 6 , 7 ] PCV is more prevalent in the Asian population with reports showing 40–55% of Japanese exudative AMD, 25% of newly diagnosed Chinese AMD, and 31.7% of Korean exudative AMD patients are PCV. [ 6 , 8 – 10 ] Numerous studies have examined the correlation between established genetic and environmental risk factors for AMD with PCV, such as CFH , ARMS2/HTRA1 genes, and smoking history, and found significant association. [ 11 – 13 ] A recent meta-analysis also confirmed similarities in genetic risk factors between AMD and PCV, even for the previously inconsistently replicated CFH Y402H variant (rs1061170).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration

et al. 2015

Self Cite

PurposeTo investigate the association of genetic and environmental factors, and their interactions in Korean patients with exudative age-related macular degeneration (AMD).MethodsA total of 314 robustly characterized exudative AMD patients, including 111 PCV (polypoidal choroidal vasculopathy) and 154 typical choroidal neovascularization (CNV), and 395 control subjects without any evidence of AMD were enrolled. Full ophthalmologic examinations including fluorescein angiography (FA), indocyanine green angiography (ICG) and optical coherence tomography (OCT) were done, according to which patients were divided into either PCV or typical CNV. Standardized questionnaires were used to collect information regarding underlying systemic diseases, dietary habits, smoking history and body mass index (BMI). A total of 86 SNPs from 31 candidate genes were analyzed. Genotype association and logistic regression analyses were done and stepwise regression models to best predict disease for each AMD subtype were constructed.ResultsAge, spherical equivalent, myopia, and ever smoking were associated with exudative AMD. Age, hypertension, hyperlipidemia, spherical equivalent, and myopia were risk factors for typical CNV, while increased education and ever smoking were significantly associated with PCV (p<.05 for all). Four SNPs, ARMS2/HTRA1 rs10490924, rs11200638, and rs2736911, and CFH rs800292, showed association with exudative AMD. Two of these SNPs, ARMS2/HTRA1 rs10490924 and rs11200638, showed significant association with typical CNV and PCV specifically. There were no significant interactions between environmental and genetic factors. The most predictive disease model for exudative AMD included age, spherical equivalent, smoking, CFH rs800292, and ARMS2 rs10490924 while that for typical CNV included age, hyperlipidemia, spherical equivalent, and ARMS2 rs10490924. Smoking, spherical equivalent, and ARMS2 rs10490924 were the most predictive variables for PCV. When comparing PCV cases to CNV cases, age, BMI, and education were the most predictive risk factors of PCV.ConclusionsOnly one locus, the ARMS2/HTRA1 was a significant genetic risk factor for Korean exudative AMD, including its subtypes, PCV and typical CNV. Stepwise regression revealed that CFH was important to risk of exudative AMD in general but not to any specific subtype. While increased education was a unique risk factor to PCV when compared to CNV, this association was independent of refractive error in this homogenous population from South Korea. No significant interactions between environmental and genetic risk factors were observed.

“…망막혈관종성증식은 망막-망막 혹은 망막-맥락막 혈관의 문합 을 특징으로 하는 삼출성 나이관련황반변성의 한 형태로 [1,2], 국내 나이관련황반변성 기초 역학조사에서는 약 6.2%를 차지 하는 것으로 나타났다 [3]. 전형적인 삼출성 나이관련황반변성 과 비교하였을 때, 망막혈관종성증식으로 진단된 환자는 비교 적 나이가 많고 양안에서 발생하며 [4,5], 드루젠이나 거짓드루 젠과 같은 망막의 연령관련 변성 소견이 더 높은 빈도로 보고 되고 있다 [6,7].…”

Section: 서론unclassified

Comparison of the Changes in Subfoveal Choroidal Thickness after Intravitreal Ranibizumab and Aflibercept Injections in Retinal Angiomatous Proliferation

Ahn

Yang

Jeon

et al. 2016

J Retin

Purpose: To compare changes in choroidal thickness after intravitreal ranibizumab and aflibercept injections in patients with retinal angiomatous proliferation (RAP). Methods: This study involved 39 eyes (21 ranimizumab-treated eyes, 18 aflibercept-treated eyes) of 36 patients who received either intravitreal ranibizumab or aflibercept injection for the first time and followed up for more than 6 months. Subfoveal choroidal thickness was measured before intravitreal injection and at 3 and 6 months after intravitreal injection to determine any significant change in subfoveal chorioidal thickness over time in each treatment group. The relevant changes at each time point were measured to compare differences between the treatment groups. Central macular thickness and the best corrected visual acuity were measured and compared. Results: Choroidal thickness at 3 and 6 months after injection was significantly lower than that before injection in both the ranibizumab and aflibercept groups (p < 0.001, in all). The changes in choroidal thickness were 17.7 ± 10.9 μm and 13.0 ± 11.0 μm at 3 and 6 months after ranibizumab injection, respectively, and 24.5 ± 12.5 μm and 18.3 ± 11. 1 μm at 3 and 6 months after aflibercept injection, respectively. These results show that although no significant differences were observed according to injection type at 3 months, the aflibercept group exhibited a significantly greater decrease at 6 months (p = 0.094, 0.043). The best corrected visual acuity in the two groups was significantly improved for up to 6 months after the injection compared with before the injection, and the central macular thickness also significantly decreased. There was no significant difference in visual improvement and central macular thickness decrease between the two groups. Conclusions: The results confirmed that both of these two drugs significantly decreased the subfoveal choroidal thickness in patients with RAP for up to 6 months after the injection, and the intravitreal injection of aflibercept tended to show a greater decrease in subfoveal choroidal thickness than the intravitreal injection of ranibizumab.