A brief summary of the uses and limitations of morphological techniques in the study of colonic cancer is presented. Problems involved in the detection of "early" colonic cancer including its definition, are discussed, as well as the question of the relationship of colonic polyps and villous tumors to the development of carcinoma. The usefulness of cytology as an adjuvant to standard investigational techniques is considered. T h e place of morphology seems secure in future studies of the pathogenesis and early detection of large bowel cancer.Cancer 34:904-908, 1974.
LL PARTICIPANTS IN THIS CONFERENCE SHAREA a common goal; the reduction of colonic and rectal cancer mortality. You will note, however, that each contributor's approach towards this goal is structured by his own acquired methodology. I am not suggesting that we can free ourselves from methodology, since scientific results probably have always been structured by investigative technique; but we can at least search for the over-all relevance of our specialty's contributions, as judged by its impact on other areas of investigation. This could help us speculate where our effort should be directed in the future and where they might he spent less profitably. T h e following is a limited attempt to do this, so far as it concerns pathology and early detection.
POLYPSWhen one mentions the pathology of early colon cancer, one's attention is apt to be focused automatically on a topic which has consumed pathologists' attention for several decades; that is, whether or not colonic polyps are p r e c a n c e r o i i~. 7~~0 ,~~,~~~~~~ T h e diagnosis and management of colonic polyps have created numerous problems for the pathologist, some inherent in the nature of the disease, and some