The results of a study on the prevalence of HIV, HCV and HBV genotypes in some regions of Ukraine

Yurchenko,; Stepchenkova, Tetiana; Karnets, Iryna; Ashworth, K.; Cheusova, Tetiana

doi:10.1186/1742-4690-9-s1-p55

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, genotype F, combined genotypes D/G, A/C, and D/F, individually, were found in Poland [42]. In Ukraine, genotype D (52.4%), followed by A (14.2%) and C (4.7%), was the most prevalent [43]. In a report of the prevalence of HBV genotypes in Central and Eastern Europe as a whole, the prevalence of genotype D was 48% and genotype A was 42%, and only a few cases of genotype B, C, E, and F were detected [44].…”

Section: Discussionmentioning

confidence: 95%

Comparison of Two Diagnostic Methods for the Detection of Hepatitis B Virus Genotypes in the Slovak Republic

et al. 2021

View full text Add to dashboard Cite

The hepatitis B virus (HBV), belonging to the Hepadnaviridae family, is responsible for a global health concern still in the 21st century. The virus is divided into 10 genotypes, which differ in geographical distribution and in their effect on disease progression and transmission, susceptibility to mutations, and response to treatment. There are many methods for diagnostics of HBV and differentiating its genotypes. Various commercial kits based on real-time polymerase chain reaction (RT PCR) and hybridization available, as well as whole genome sequencing or the sequencing of only individual parts of the genomes. We compared a commercial kit AmpliSens HBV-genotype-FRT, based on RT PCR, with an adapted method of amplification of the surface genomic region combined with Sanger sequencing. In the examined samples we identified the A, B, C, D, and E genotypes. By PCR with Sanger sequencing, the genotypes were determined in all 103 samples, while by using the commercial kit we successfully genotyped only 95 samples, including combined genotypes, which we could not detect by sequencing.

show abstract

Section: Discussionmentioning

confidence: 95%

Comparison of Two Diagnostic Methods for the Detection of Hepatitis B Virus Genotypes in the Slovak Republic

et al. 2021

View full text Add to dashboard Cite

show abstract

“…У больных с хронической инфекцией генотипы А и D встречаются приблизительно одинаково часто (41,8 и 39,2 %). Похожие данные были обнаружены в другом исследовании на меньшей выборке больных [8].…”

unclassified

Генотипы HBV И Противовирусная Терапия Гепатита В

Зайцев¹,

Novak²,

Zaitseva³

et al. 2021

View full text Add to dashboard Cite

В 1988 году Okamoto с соавт. впервые сравнили полную нуклеотидную последовательность 18 штаммов вируса гепатита В (HBV) и обнаружили несоответствие, которое позволило отнести исследуемые вирусы к одному из 4 кластеров, названных впоследствии генотипами А, В, С и D [1]. В последующем были открыты еще 6 генотипов HBV (обозначаются буквами от А до J). Генотипы отличаются длиной генома, размером открытого для чтения региона и трансляцией белка, а также развивающимися под влиянием терапии мутациями [2,3]. Некоторые генотипы подразделяются на

show abstract

Distribution of Hepatitis B Virus Genotypes in Azerbaijani Patients With Chronic Hepatitis B Infection

et al. 2014

View full text Add to dashboard Cite

Background:Hepatitis B virus (HBV) has been classified into ten genotypes (A-J) based on genome sequence divergence, which is very important for etiological and clinical investigations. HBV genotypes have distinct geographical distributions worldwide.Objectives:The aim of this study was to investigate the distribution of HBV genotypes among Azerbaijani patients with chronic hepatitis B, came from the Republic of Azerbaijan country to Iran to receive medical care.Patients and Methods:One hundred and three patients with chronic HBV infection, referred to hospitals related to Iran University of Medical Sciences and Tehran Hepatitis Center from August 2011 to July 2014, were enrolled in this cross sectional study. About 3-milliliter of peripheral blood was taken from each patient. After viral DNA extraction, HBV genotypes were tested using the INNO-LiPA™ HBV kit (Innogenetics, Ghent, Belgium). HBV genotyping was confirmed using sequencing of hepatitis B surface antigen (HBsAg) and polymerase (pol) regions of HBV.Results:The mean age of patients was 35.9 ± 11.7 years (19-66). Of 103 patients, 72 (69.9%) were male. In the present study, the predominant HBV genotype was D (93.2%) followed by genotype A (5.8%) and concurrent infection with A and D genotypes (0.97%).Conclusions:The main and frequent HBV genotype among Azerbaijani patients with chronic hepatitis B virus infection was genotype D followed by genotype A.

show abstract

The results of a study on the prevalence of HIV, HCV and HBV genotypes in some regions of Ukraine

Cited by 3 publications

References 0 publications

Comparison of Two Diagnostic Methods for the Detection of Hepatitis B Virus Genotypes in the Slovak Republic

Comparison of Two Diagnostic Methods for the Detection of Hepatitis B Virus Genotypes in the Slovak Republic

Генотипы HBV И Противовирусная Терапия Гепатита В

Distribution of Hepatitis B Virus Genotypes in Azerbaijani Patients With Chronic Hepatitis B Infection

Contact Info

Product

Resources

About