The restriction point and control of cell proliferation

Planas-Silva, Maricarmen D.; Weinberg, Robert A.

doi:10.1016/s0955-0674(97)80076-2

Cited by 220 publications

(161 citation statements)

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“…By comparing Figs. 2 and 3, we see that passage through the restriction point coincides with phosphorylation of Rb Planas-Silva and Weinberg, 1997). The fixed time to reach the restriction point (3 h) is determined by the kinetic constants governing the interactions among CycD, CycE, Rb, E2F, and Kip1.…”

Section: Zetterberg-larsson Experimentsmentioning

confidence: 85%

“…CycD/Cdk4 stimulates cell growth and division by phosphorylating the retinoblastoma protein, Rb (Weinberg, 1995;Planas-Silva and Weinberg, 1997). Rb is a general inhibitor of RNA polymerases (White, 1997) and a specific inhibitor of E2F, a transcription factor for the CycA and CycE genes DeGregori, 2002).…”

Section: The Retinoblastoma Proteinmentioning

confidence: 99%

“…If GFs are deprived, cells early in G1 phase leave the cycle and enter a resting state (G0); older cells finish the ongoing cycle and enter the resting state after mitosis. The point in G1, before which cells enter directly into the resting state, is called the restriction point (Pardee, 1989;Bartek et al, 1996;Planas-Silva and Weinberg, 1997). (A glossary of technical terms used in this paper is provided in Table 1.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A model for restriction point control of the mammalian cell cycle

Novák

Tyson

2004

Journal of Theoretical Biology

268

279

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Section: Zetterberg-larsson Experimentsmentioning

confidence: 85%

Section: The Retinoblastoma Proteinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A model for restriction point control of the mammalian cell cycle

Novák

Tyson

2004

Journal of Theoretical Biology

268

279

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“…Progression through the cell cycle is driven by the cyclin-dependent kinase (CDK) family of serine/threonine kinases and their regulatory partners the cyclins [6]. Cyclin D-CDK4, cyclin D-CDK6 and cyclin E-CDK2 drive G 1 progression through the restriction point, which commits the cell to complete the cycle [7]. S phase is initiated by cyclin A-CDK2, and cyclin B-CDK1 regulates progression through G 2 and entry into mitosis [8].…”

Section: Introductionmentioning

confidence: 99%

The cell cycle and cancer

Williams

Stoeber

2011

The Journal of Pathology

565

406

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Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past two decades, cancer genetics has shown that hyperactivating mutations in growth signalling networks, coupled to loss of function of tumour suppressor proteins, drives oncogenic proliferation. Gene expression profiling of these complex and redundant mitogenic pathways to identify prognostic and predictive signatures and their therapeutic targeting has, however, proved challenging. The cell cycle machinery, which acts as an integration point for information transduced through upstream signalling networks, represents an alternative target for diagnostic and therapeutic interventions. Analysis of the DNA replication initiation machinery and mitotic engine proteins in human tissues is now leading to the identification of novel biomarkers for cancer detection and prognostication, and is providing target validation for cell cycle-directed therapies.

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“…There is a window of time, the restriction point, in the early/ mid G1 phase of the cell cycle during which mammalian cells are responsive to extracellular signals such as growth factors or nutrients. At this time period, the retinoblastoma (Rb) protein, which enables the cells to pass through the restriction point and to complete the remaining phases of the growth cycle, is phosphorylated in the presence of growth factors [1,2]. Other than G1/S transition, however, growth factors have been considered non-essential on the proliferating cell cycle [3].…”

mentioning

confidence: 99%