The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs

Fibrous Scaffolds with Varied Fiber Chemistry and Growth Factor Delivery Promote Repair in a Porcine Cartilage Defect Model

“…14 Other materials investigated in cartilage defects with microfracture include HA, 15 alginate, 16 and poly(lactide-co-glycolide) (PLGA) sponges embedded with a fibrin gel. 17 Similarly, electrospun poly(vinyl alcohol) (PVA) and chondroitin sulfate (CS) fibers have been investigated in rat osteochondral defects, with CS fibers increasing glycosaminoglycan (GAG) and type 2 collagen deposition. 18 Even with these advances, research toward engineering novel biomaterials to improve repair outcomes following microfracture is limited, and the influence of scaffold properties on in vivo cartilage repair is still not well understood.…”

Bioactive Scaffolds for the Controlled Formation of Complex Skeletal Tissues

“…Longer GF retention times can be achieved by modifications in the GF (Schmoekel et al, 2004), by integrating high GF-affinity moieties in the fibrin chains (Merritt et al, 2010), or by covalent linking of the GFs (Drinnan et al, 2010;Schmoekel et al, 2005). Examples of GFs that have been integrated in fibrin gels in skeletal tissue engineering applications include BMP-2 (Kang et al, 2011;Schmoekel et al, 2004;Schmoekel et al, 2005), TGF-1 and TGF-3 (Drinnan et al, 2010;W. Wang et al, 2010b).…”

“…To address these limitations, fibrin glue scaffolds can be optimized by using a solid porous scaffold for reinforcement (Schagemann et al, 2010;Z.H. Wang et al, 2010a;W. Wang et al, 2010b), or by the use of enzymatic inhibitors (Fussenegger et al, 2003).…”

“…Lee et al, 2011). Wang et al used polyester/fibrin gel constructs loaded with MSCs and TGF-1 to promote restoration of full-thickness cartilage defects (W. Wang et al, 2010b). Also recently, Scotti et al used fibrin gels to promote cell adhesion to devitalized spongiosa cylinders used for engineering osteochondral grafts (Scotti et al, 2010).…”

A preclinical evaluation of an autologous living hyaline-like cartilaginous graft for articular cartilage repair: a pilot study

“…Its principle involves combining a variety of cell sources, scaffold materials and bioactive factors to aid cartilage repair [18][19][20] . This appears to be advantageous over the direct usage of cells, which may be implicated by cell handling and delivery issues 15 .…”