The Responsiveness of Thymic Stromal Cells to semaphorin-3A

Lins, Marvin Paulo; Medeiros, Návylla Candeia de; Carmo, Julianderson de Oliveira dos Santos; Porto, Felipe Lima; Reis, Marlon M.; Smaniotto, Salete

doi:10.1080/08820139.2020.1834578

Cited by 5 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also found that ACTH and IL-1β expressions were regulated by Tβ15, but because of their immunomodulatory effects on Treg cells and B cells, functional studies of these cells are needed to draw more definitive conclusions [ 44 , 45 , 46 ]. Sema 3A is a soluble protein involved in cell adhesion and migration and can also reduce the number of F-actin-enriched protrusions [ 47 , 48 , 49 ]. Sema-3A was expressed in high levels in Tβ15 OX iTECs.…”

Section: Discussionmentioning

confidence: 99%

Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells

Hoffman

et al. 2022

Cells

View full text Add to dashboard Cite

The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the thymus response to the external environment. Thymosin beta 15 (Tβ15) is a G-actin binding protein secreted by TECs, it plays an important role in maintaining the dynamic balance of actin, angiogenesis, axonal formation, and wound healing, but the relationship between Tβ15 and TECs is not clear yet. Here, we show the impact of Tβ15 on the TEC’s spatial development, as well as the T-cell differentiation and thymic output. As a result, TEC is the main effector cell of Tβ15 in the thymus. Tβ15 OX inhibits the chemotaxis of TECs to the medulla and subsequently blocks the positive selection of thymocytes from CD3+TCRβ+CD4+CD8+ double positive cells to CD3+TCRβ+CD4+CD8- single-positive (CD4SP) cells. Tβ15-knockdown accelerates the reticular differentiation of astral TECs and medullary TECs. Importantly, mice implanted with Tβ15-knockdown iTECs show high thymic output but low peripheral T cell maturity and activity. In a word, our results explain the role of Tβ15 on the differentiation and function of TECs and provide a new perspective for understanding the process of thymus development and degeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells

Hoffman

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…This receptor plays a role in embryonic development, angiogenesis, and cell migration. In addition, NRP-1 expression has been detected in thymic stromal cells and TECs, and has been demonstrated to have an effect on thymic physiology (Lins et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…The deposition of LM in the thymus is under hormonal regulation, such as GH, which increases the deposition of LM in TECs in vitro , or under the regulation of triiodothyronine (T3), which enhances intrathymic expression of LM. Also, Sema-3A increases LM production in thymic stromal cells (Lins et al 2020 ). Similarly, mice that were administered intraperitoneal glucocorticoids (GCs) exhibited a greater amount of LM within the thymic lobes.…”

Section: Discussionmentioning

confidence: 99%