The United Nations Security Council Resolution No. 2664 is a trailblazing development in the protection of humanitarian interests in the context of sanctions regimes. Adopted after strenuous and tough negotiations, the Resolution introduces a humanitarian carve-out to almost all asset-freezing sanctions, exempting humanitarian operations from the scope of application of UN sanction regimes. This represents a momentous achievement towards prioritizing and safeguarding the needs and interests of humanitarian organizations and actors. Indeed, economic sanctions as instruments to achieve policy objectives raise challenges as they restrict entire economies, thus bringing severe consequences for the populations of the targeted states. Targeted sanctions, however, can be difficult to implement, as the activities of targeted individuals or groups and legitimate humanitarian actors can often overlap from a financial standpoint. The humanitarian carve-out introduced by Resolution No. 2664 aims at addressing these issues; and while the effectiveness of the carve-out will depend largely on its implementation and enforcement, the rationale behind the Resolution should be adopted as the standard for current and future sanctions regimes. This article argues that Resolution No. 2664 has the potential to transform the way sanctions are implemented and enforced, and is therefore a crucial development in the UN's effort to protect and promote human rights.