The Response to Vibration of the End Organs of Mammalian Muscle Spindles

Bianconi, R; Meulen, Joseph P. Van Der

doi:10.1152/jn.1963.26.1.177

Cited by 187 publications

(103 citation statements)

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“…Neurons were considered to respond to activated muscle proprioceptors when they (1) were sensitive to sinusoidal muscle stretching (Lundberg and Winsbury, 1960;Bianconi and van der Meulen, 1963;Brown et al, 1967;Matthews and Stein, 1969;Stuart et al, 1970;Mackie et al, 1998), showing a tight phase locking at the tested frequencies of 130 -135 Hz (Mackie et al, 1998); (2) produced spike bursting during stretching, a rapid drop in discharge on completion of the dynamic phase of stretching, and then a relatively slow drop during the holding phase (Matthews, 1933;Harvey and Matthews, 1961;Matthews, 1981;Edin and Vallbo, 1990); and (3) showed silenced firing during muscle shortening (stretch release) (Matthews, 1981;Edin and Vallbo, 1990;Grill and Hallet, 1995). It became clear during the first successful experiments in three distinct animals that cells responding in a 1:1 fashion to 130 -135 Hz muscular sinusoidal vibration also responded to manual muscle stretch (by flexing or extending the appropriated articulation), showing bursting discharges during the dynamic phase of stretching followed by a fall in discharge rate during holding and silenced firing during shortening.…”

Section: Methodsmentioning

confidence: 99%

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Leiras¹,

Velo²,

Martín-Cora³

et al. 2010

J. Neurosci.

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Medial lemniscal activity decreases before and during movement, suggesting prethalamic modulation, but the underlying mechanisms are largely unknown. Here we studied the mechanisms underlying proprioceptive transmission at the midventral cuneate nucleus (mvCN) of anesthetized cats using standard extracellular recordings combined with electrical stimulation and microiontophoresis. Dual simultaneous recordings from mvCN and rostroventral cuneate (rvCN) proprioceptive neurons demonstrated that microstimulation through the rvCN recording electrode induced dual effects on mvCN projection cells: potentiation when both neurons had excitatory receptive fields in muscles acting at the same joint, and inhibition when rvCN and mvCN cells had receptive fields located in different joints. GABA and/or glycine consistently abolished mvCN spontaneous and sensory-evoked activity, an effect reversed by bicuculline and strychnine, respectively; and immunohistochemistry data revealed that cells possessing strychnine-sensitive glycine receptors were uniformly distributed throughout the cuneate nucleus. It was also found that proprioceptive mvCN projection cells sent ipsilateral collaterals to the nucleus reticularis gigantocellularis and the mesencephalic locomotor region, and had slower antidromic conduction speeds than cutaneous fibers from the more dorsally located cluster region.The data suggest that (1) the rvCN-mvCM network is functionally related to joints rather than to single muscles producing an overall potentiation of proprioceptive feedback from a moving forelimb joint while inhibiting, through GABAergic and glycinergic interneurons, deep muscular feedback from other forelimb joints; and (2) mvCN projection cells collateralizing to or through the ipsilateral reticular formation allow for bilateral spreading of ascending proprioceptive feedback information.

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Section: Methodsmentioning

confidence: 99%

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Leiras¹,

Velo²,

Martín-Cora³

et al. 2010

J. Neurosci.

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“…5. The size of the reflex tension from TVR-f relation depends on the discharge frequency of the unitary EMG, which occurs according to the principle of the integer multiplication of original vibratory cyclic time.It has been demonstrated in cat musclethat primary spindle endings are much more sensitive to muscle vibration than secondary endings, their maximal response frequency being around 400Hz (GRANIT and HENATSCH, 1956;BESSOU and LAPORT, 1962;BIANCONI and VAN DER MEULEN, 1963;BROWN et al, 1967). It has also been reported by several authors that group Ia afferent discharges elicited by sinusoidal stretch activate the spinal motoneuron monosynaptically (MATTHEWS, 1966;HOMMA et al, 1967).…”

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confidence: 93%

Tonic Vibration Reflex in Human and Monkey Subjects

1971

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Summary 1. Both in human subjects and monkeys, the tonic vibration reflex, TVR, was observed during vibratory stimulation of the muscle. In the latter, TVR reaches its maximum soon after vibratory application. 2. In the monkey, unitary EMG was recorded during vibratory stimulation and nonsequential interspike interval histograms were obtained. Intervals of unitary EMG were shown to occur on the principle of integer multiplication of the vibratory cyclic time. 3. A gradual increase or decrease of TVR during vibratory stimulation in the human subject or the monkey is effected by the EMG discharges of shorter or longer firing intervals which occur on this principle. 4. Both in human subjects and monkeys, the TVR becomes larger with the higher range of vibratory frequency. Beyond a certain vibratory frequency the TVR shows a gradual decrease. The relationship between the TVR and the vibratory frequency was called the TVR-f relation. There is an optimal frequency of vibratory stimulation for producing the largest TVR tension. 5. The size of the reflex tension from TVR-f relation depends on the discharge frequency of the unitary EMG, which occurs according to the principle of the integer multiplication of original vibratory cyclic time.It has been demonstrated in cat musclethat primary spindle endings are much more sensitive to muscle vibration than secondary endings, their maximal response frequency being around 400Hz (GRANIT and HENATSCH, 1956;BESSOU and LAPORT, 1962;BIANCONI and VAN DER MEULEN, 1963;BROWN et al., 1967). It has also been reported by several authors that group Ia afferent discharges elicited by sinusoidal stretch activate the spinal motoneuron monosynaptically (MATTHEWS, 1966;HOMMA et al., 1967).Vibration of the muscle tendon in awake human subject causes a gradual

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“…Vibration can also stimulate muscle spindle afferents causing healthy subjects to erroneously perceive that the vibrated muscle has lengthened and their limb has moved (Goodwin et al 1972;Roll and Vedel 1982). This effect is caused by muscle vibration triggering activity in primary muscle spindle afferents which is sensed as further stretching of the muscle (Bianconi and van der Meulen 1963;Burke et al 1976;Roll and Vedel 1982). Biguer et al (1998) demontrated that dorsal neck vibration in the upright position causes a visual illusion of displacement of a visual target away from the side of vibration in normal subjects and suggested this was due to neck muscle proprioceptive stimulation.…”

Section: Introductionmentioning

confidence: 99%

Neck Muscle Vibration Alters Visually Perceived Roll in Normals

McKenna

Peng

Zee

2004

JARO - Journal of the Association for Research in Otolaryngolog

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The objective of this study was to determine whether vibration of dorsal neck muscles or of the mastoid bone or of both modified the perception of visual orientation in the head roll-tilt plane in normal subjects. Measurements of the subjective visual vertical (SVV) were obtained from 26 normal human subjects. Subjects reported the SVV in the upright and in the left and right 30°static head roll-tilt positions. Subjects then reported the SVV while vibration was applied to the left or right dorsal neck or left or right mastoid. Both head position and vibration independently modified settings of the SVV. In head-tilted positions, vibration of the upper dorsal neck muscles (on the side of the head opposite to the head tilt) caused a significantly greater shift of the SVV in the opposite direction of head roll-tilt compared to vibration of the lower dorsal neck muscles or of the mastoid. These results support a role for cervical somatosensory information in perception of visual orientation in the roll plane. Our findings may help explain the differences observed in visual orientation perception in normal subjects between head alone and whole-body roll-tilt. Finally, vibration of neck muscles in the head roll-tilted plane may be a useful method to test cervical somatosensory function possibly by increasing their response to external stimulation.

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The Response to Vibration of the End Organs of Mammalian Muscle Spindles

Cited by 187 publications

References 0 publications

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Tonic Vibration Reflex in Human and Monkey Subjects

Neck Muscle Vibration Alters Visually Perceived Roll in Normals

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