The response to hepatitis B vaccine: does it differ in celiac disease?

Ertem, Deniz; Gönen, İsmail; Tanıdır, Cansaran; Uğraş, Meltem; Yildiz, Aysegul; Pehlivanoğlu, Ender; Ekşioğlu-Demiralp, Emel

doi:10.1097/meg.0b013e32832e9d41

Cited by 39 publications

(56 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Conversely, 3 of 10 (30%) patients with CD who completed vaccination at or after one year of age failed to develop anti-HBs. Ertem et al (11) reported that the response to HBV vaccine in celiac children who were compliant with a gluten-free diet was not different from that of healthy controls. They suggested that compliance with the glutenfree diet may ameliorate the immune response to HBV vaccine in children with CD.…”

Section: Discussionmentioning

confidence: 99%

Responsiveness of children with celiac disease to different hepatitis B vaccination protocols

Balamtekin

Uslu²,

Baysoy³

et al. 2011

Turk J Gastroenterol

View full text Add to dashboard Cite

Celiac disease (CD) is a common autoimmune disease characterized by permanent intolerance to ingested gluten, which results in immune-mediated injury of the small bowel mucosa. Genetic, environmental and immunological factors are responsible for the disease. Susceptibility to CD is determined, in part, by a common human leukocyte antigen (HLA) association; specifically, the major histocompatibility complex class II antigen DQ2, which is present in 86% to 100% of the patients (1).Hepatitis B virus (HBV) infection is one of the most important public health problems worldwide. HBV infection acquired during the perinatal, infancy and early childhood periods is a major cause of chronic liver disease and liver cancer (2). Hepatitis B vaccine is highly effective and safe, and it can prevent the morbidity and occasional mortality associated with infection (3). For this reason, HBV vaccine is considered as the main strategy in the control of the infection and viral transmission. HBV vaccine was introduced into clinical practice

show abstract

Section: Discussionmentioning

confidence: 99%

Responsiveness of children with celiac disease to different hepatitis B vaccination protocols

Balamtekin

Uslu²,

Baysoy³

et al. 2011

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…94 However, the response to HBV vaccine in coeliac children who were compliant with a gluten-free diet is no different from that of the healthy population. 95 Thus, coeliac disease may be one of the immune diseases associated with a reduced response to HBV vaccine; however, this lack of response might not be permanent, and a gluten-free diet and compliance with treatment may ameliorate the immune response to the vaccine. 95 In this respect, Melmed et al 92 evaluated immunogenicity with the 23-valent pneumococcal polysaccharide vaccine in IBD patients receiving both anti-TNF agents and immunomodulators, IBD patients not receiving any immunosuppressive therapy, and in healthy controls.…”

Section: What Factors Affect the Efficacy Of Hbv Vaccination In Ibd Pmentioning

confidence: 99%

“…95 Thus, coeliac disease may be one of the immune diseases associated with a reduced response to HBV vaccine; however, this lack of response might not be permanent, and a gluten-free diet and compliance with treatment may ameliorate the immune response to the vaccine. 95 In this respect, Melmed et al 92 evaluated immunogenicity with the 23-valent pneumococcal polysaccharide vaccine in IBD patients receiving both anti-TNF agents and immunomodulators, IBD patients not receiving any immunosuppressive therapy, and in healthy controls. Inflammatory bowel disease patients who received combination immunosuppressive therapy mounted a less effective immune response than patients with IBD who received non-immunosuppressive therapy and controls, both of which exhibited a similar good response.…”

Section: What Factors Affect the Efficacy Of Hbv Vaccination In Ibd Pmentioning

confidence: 99%

Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease

Gisbert

Chaparro

Esteve

2011

Alimentary Pharmacology &Amp; Therapeutics

105

View full text Add to dashboard Cite

“…Gluten might be implicated because both hepatitis B surface antigen (HBsAg) protein fragments and gliadin peptides bind to HLA-DQ2 molecules and induce proliferation of T lymphocytes. Competition between the proteins may result in defective antibody production (6)(7)(8).…”

mentioning

confidence: 99%

Role of Gluten Intake at the Time of Hepatitis B Virus Vaccination in the Immune Response of Celiac Patients

Zingone¹,

Capone²,

Tortora³

et al. 2013

Clin. Vaccine Immunol.

View full text Add to dashboard Cite

bSome reports have demonstrated an inadequate response to hepatitis B vaccination in patients affected by celiac disease. The aim of our study was to evaluate hepatitis B vaccination response in relation to gluten exposure status in patients with celiac disease. To measure the gluten exposure status at the time of vaccination, we considered three groups: group A (exposed to gluten), including patients vaccinated as 12-year-old adolescents (the celiac disease diagnosis was established after vaccination); group B (not exposed to gluten), including patients vaccinated as 12-year-old adolescents on a gluten-free diet at the time of vaccination; and group C (infants), including patients vaccinated at birth. The response of celiac patients to hepatitis B vaccination was compared to that of healthy subjects, i.e., those in the control group (group D). This study included 163 celiac patients (group A, 57 patients; group B, 46 patients; and group C, 60 patients) and 48 controls (group D). An inadequate response to hepatitis B immunization was present in 43.9% of patients in group A, 34.8% of patients in group B, 58.3% of patients in group C, and 8.3% of patients in group D (group A versus group D, P < 0.001; group B versus group D, P ‫؍‬ 0.002; group C versus group D, P ‫؍‬ 0.001) (no significant difference for group A versus group B and group A versus group C was evident). Our data suggest that gluten exposure does not influence the response to hepatitis B immunization and that the human leukocyte antigen probably plays the main immunological role in poor responses to hepatitis B-vaccinated celiac patients. Several studies have reported an inadequate response to hepatitis B virus (HBV) vaccination in patients affected by celiac disease (CD). Unfortunately, the causes of this impaired response are unknown (1-8).In the general population, it is recognized that several factors influence the production of protective levels of antibodies against HBV after the standard immunization. Well-known modifiers include age, obesity, smoking, drug abuse, alcoholism, infections, immune suppression, and the route of vaccination (9, 10). Additionally, hepatitis B vaccine nonresponsiveness, due to the presence of specific human leukocyte antigen (HLA) genotypes, has been described (11-13).Celiac disease (CD) is an HLA-associated immunological disease, and for this reason, a genetic predisposition as a possible cause of a lower grade of immunization to recombinant hepatitis B vaccines has been considered (4, 5). In fact, HLA-DQ2 status may predispose CD patients to fail to develop immunity after hepatitis B vaccination through a Th2 response that is inadequate for B-cell differentiation and the formation of memory B cells (5). In contrast, several studies have hypothesized gluten intake as a cause of failed immunity at the time of vaccination. Gluten might be implicated because both hepatitis B surface antigen (HBsAg) protein fragments and gliadin peptides bind to HLA-DQ2 molecules and induce proliferation of T lymphocytes. Competition bet...

show abstract

The response to hepatitis B vaccine: does it differ in celiac disease?

Cited by 39 publications

References 33 publications

Responsiveness of children with celiac disease to different hepatitis B vaccination protocols

Responsiveness of children with celiac disease to different hepatitis B vaccination protocols

Review article: prevention and management of hepatitis B and C infection in patients with inflammatory bowel disease

Role of Gluten Intake at the Time of Hepatitis B Virus Vaccination in the Immune Response of Celiac Patients

Contact Info

Product

Resources

About