The response of X‐irradiated limbs of adult urodeles to normal tissue grafts. I. Effects of autografts of sixty‐day forearm regenerates

Stinson, Benjamin D.

doi:10.1002/jez.1401530105

Cited by 16 publications

(5 citation statements)

References 37 publications

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“…Dorsal and ventral half stylopodia regenerate with the normal AP pattern and number of digits, but are deficient in ventral and dorsal muscle, respectively (Maden, 1979a, b; Wigmore & Holder, 1986). Posterior half and anterior half zeugopodia of forelimbs each regenerate their half of the zeugopodium plus half the digits (Goss, 1957a, b; Stinson, 1963, 1964a, b, c). Dorsal and ventral half forelimb zeugopodia regenerate limbs normal in the AP axis, but deficient in ventral and dorsal muscle, respectively (Wigmore, 1986).…”

Section: Pattern Formation In the Blastemamentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

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This review explores the historical and current state of our knowledge about urodele limb regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of limb tissues to release resident stem cells and mononucleate cells that undergo dedifferentiation, cell cycle entry and accumulation under the apical epidermal cap. (2) The origin, phenotypic memory, and positional memory of blastema cells. (3) The role played by macrophages in the early events of regeneration. (4) The role of neural and AEC factors and interaction between blastema cells in mitosis and distalization. (5) Models of pattern formation based on the results of axial reversal experiments, experiments on the regeneration of half and double half limbs, and experiments using retinoic acid to alter positional identity of blastema cells. (6) Possible mechanisms of distalization during normal and intercalary regeneration. (7) Is pattern formation is a self‐organizing property of the blastema or dictated by chemical signals from adjacent tissues? (8) What is the future for regenerating a human limb?

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Section: Pattern Formation In the Blastemamentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

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“…One of the first such experiments was done by Stinson [91,92,93,941. He autografted either the whole lower arm or the anterior or posterior half of the lower arm from unirradiated right forelimbs into the upper arm of irradiated left forelimbs in adult Notophthalmus viridescens.…”

Section: The Young Hlastema Is Completely Self-organizing and Non-plumentioning

confidence: 99%

The urodele limb regeneration blastema

Stocum

1984

Differentiation

118

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“…Although irradiated salamander limbs lose their capacity to regenerate, Stinson found through a series of irradiation and grafting experiments in adult newts (a subfamily of salamanders) that regeneration could be induced when tissue from nonirradiated limbs was grafted from the same animal and amputated. Moreover, regenerated tissues exhibited the character of the donor grafts rather than that of the irradiated host limb (eg, handedness, digit number). These experiments provide strong evidence that positional information is specified and preserved at a cellular level within tissues of the limb.…”

Section: A Brief History Of Salamander Limb Regeneration Researchmentioning

confidence: 99%

Remembering where we are: Positional information in salamander limb regeneration

Flowers

Crews

2020

Developmental Dynamics

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Fifty years ago, Lewis Wolpert defined an important question in developmental biology: how are cell fates determined by the positions of cells within a system? He proposed that cells retain positional values as if they lie within a coordinate system and that the interpretation of these values produces patterns in development. He referred to this concept as positional information. Though initially controversial, this concept of positional information has proven to be profoundly influential in developmental biology. One area in which the influence of Wolpert's theoretical work can be clearly demonstrated is the study of limb regeneration in salamanders. Here, we review the work in limb regeneration leading up to Wolpert defining the concept of positional information and how his theory has guided regeneration research over the subsequent 50 years.

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The response of X‐irradiated limbs of adult urodeles to normal tissue grafts. I. Effects of autografts of sixty‐day forearm regenerates

Cited by 16 publications

References 37 publications

Mechanisms of urodele limb regeneration

Mechanisms of urodele limb regeneration

The urodele limb regeneration blastema

Remembering where we are: Positional information in salamander limb regeneration

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