The response of the dog kidney to transplant rejection or ischaemia: An experimental and comparative study with functional, microcirculatory and enzymological investigations

Abstract

Abstract. 1. The effects of transplant rejection or of total ischaemia on the dog kidney were compared by studying the following parameters: urinary clearances, microcirculation, histological aspect, blood levels of lysosoma] enzymes, active transport of cortical slices, and levels of cortical ATPases.2. At the point of rejection, allotransplanted kidneys without immunosuppressire therapy maintained almost normal active transport of glycine and fl-methylglucoside by the proximal tubular epithelium, despite greatly reduced microcirculation and abolition of glomerular filtration.3. 1 or 2 hours' ischaemia provoked partial tubular necrosis with an abrupt liberation of lysosomal enzymes into the circulation and a decrease in active transport. The mierocirculation was less damaged. 2 days later, in spite of the partial recovery of the active transport, and discrete zones of cellular regeneration, the clearances were still non-existent.4. The results suggest that there is little correlation between the effects of allotransp]ant rejection and ischaemia. The primary event in the process of rejection involves the interruption of the glomerular circulation, which leads to a rapid cessation of urine formation, without too much damage to the transport function of the tubular epithelium.

Individual course of experimental acute renal failure: Morphology, function, plasma renin activity

“…Als Modell des ANV ist die aknte Niereninsuffizienz nach tcmpor~rer Isch£mie besonders geeignet, weil auf Grund friiherer Untersuchungen funktionelle, bioehemische und morphologische Kriterien vorliegen [8,13,16,18,22,25,27,28,34].…”