The Response of Osteoblast-Like SaOS-2 Cells to Modified Titanium Surfaces

Pivodová, Veronika; Franková, Jana; Doležel, Petr; Ulrichová, Jitka

doi:10.11607/jomi.3039

Cited by 14 publications

(16 citation statements)

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“…The surface microtopography is a crucial parameter, especially in the dental field, where optimal roughness has been suggested to be around 1.5 m in terms of the S a value [24,25]. This is a size range which may stimulate osteoblast attachment, proliferation and differentiation, resulting in greater bone formation [26]. In the present study, a different magnitude of roughness was evaluated, with S a values of 10 m. This is characteristic of an as-built surface using the EBM technique, where particles 40-100 m in size are the starting material.…”

Section: Discussionmentioning

confidence: 99%

Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting

Stenlund

Kurosu

Koizumi

et al. 2015

Additive Manufacturing

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Section: Discussionmentioning

confidence: 99%

Osseointegration Enhancement by Zr doping of Co-Cr-Mo Implants Fabricated by Electron Beam Melting

Stenlund

Kurosu

Koizumi

et al. 2015

Additive Manufacturing

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“…These experiments are followed by in vivo experiments, in order to verify the findings obtained in vitro, and also to investigate the effects of the material modifications on the whole organism. It was shown that physical surface treatments (such as surface roughness) play a more important role than chemical modifications 30 . Proper implant modification should result in improved bone-implant attachment and increased mechanical resistance after implantation.…”

Section: An Overview Of Titanium Implant Surface Modificationsmentioning

confidence: 99%

Treatments for enhancing the biocompatibility of titanium implants

Štěpanovská¹,

Matějka²,

Rosina³

et al. 2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Titanium surface treatment is a crucial process for achieving sufficient osseointegration of an implant into the bone. If the implant does not heal sufficiently, serious complications may occur, e.g. infection, inflammation, aseptic loosening of the implant, or the stress-shielding effect, as a result of which the implant may need to be reoperated. After a titanium graft has been implanted, several interactions are crucial in order to create a strong bone-implant connection. It is essential that cells adhere to the surface of the implant. Surface roughness has a significant influence on cell adhesion, and also on improving and accelerating osseointegration. Other highly important factors are biocompatibility and resistance to bacterial contamination. Bio-inertness of titanium is ensured by the protective film of titanium oxides that forms spontaneously on its surface. This film prevents the penetration of metal compounds, and it is well-adhesive for calcium and phosphate ions, which are necessary for the formation of the mineralized bone structure. Since the presence of the film alone is not sufficient for the biocompatibility of titanium, a suitable surface finish is required to create a firm bone-implant connection. In this review, we explain and compare the most widely-used methods for modulating the surface roughness of titanium implants in order to enhance cell adhesion on the surface of the implant, e.g. plasma spraying, sandblasting, acid etching, laser treatment, sol-gel etc., The methods are divided into three overlapping groups, according to the type of modification. ) is gratefully acknowledged for his language revision of the manuscript. We also thank the Prospon s.r.o. company (Kladno, Czech Republic) for providing Ti6Al4V samples for studies on cell-material interaction.

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“…23,24 Physical treatment is the first possible approach for biomaterial modification. 25,26 Advantages of acid etching include high maneuverability, low cost, and non-toxity. 27 However, studies on acid-processed dentin have focused generally on dental acid corrosion materials rather than altering the characteristics of dentin for application as possible bone substitute material for clinical application.…”

Section: Introductionmentioning

confidence: 99%

“…Physical treatment is the first possible approach for biomaterial modification 25 , 26 . Advantages of acid etching include high maneuverability, low cost, and non‐toxity 27 .…”

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confidence: 99%