1968
DOI: 10.1203/00006450-196807000-00001
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Abstract: ExtractLitter-mate homozygous and heterozygous weanling rats of the Gunn strain were thirsted and fasted for 24 hours. The response of the animals to thirsting was compared by analysis of solute content of serum and composition of fluid in the renal medullae. The results are given in tables I and II. When the mean values for weight loss and serum solute concentrations were compared, it was found that the jaundiced rats were able to conserve body water as well as the non-jaundiced rats and to generate equally h… Show more

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Cited by 2 publications
(5 citation statements)
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“…After 24 h of fluid deprivation, the jj animals only attained a Um.. of approximately 1,500 mosmol/kg H20, while their normal Jj littermates without the defect achieved a U... of approximately 2,500 mosmol/kg H20 (see Table I). These results conflict with previously published observations of Odell (7), who reported finding no significant difference in the urea and nonurea solute concentrations of the inner medulla in weanling jj and Jj rats and concluded that jaundiced weanling jj rats up to 21 days of age have normal medullary function. However, Odell (7) did not determine urine osmolality in the two groups of animals, which would have been a more sensitive method of estimating urine concentrating ability, and this may explain, at least in part, his failure to detect a defect in U.as in the jaundiced weanling jj rats.…”
Section: Resultscontrasting
confidence: 57%
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“…After 24 h of fluid deprivation, the jj animals only attained a Um.. of approximately 1,500 mosmol/kg H20, while their normal Jj littermates without the defect achieved a U... of approximately 2,500 mosmol/kg H20 (see Table I). These results conflict with previously published observations of Odell (7), who reported finding no significant difference in the urea and nonurea solute concentrations of the inner medulla in weanling jj and Jj rats and concluded that jaundiced weanling jj rats up to 21 days of age have normal medullary function. However, Odell (7) did not determine urine osmolality in the two groups of animals, which would have been a more sensitive method of estimating urine concentrating ability, and this may explain, at least in part, his failure to detect a defect in U.as in the jaundiced weanling jj rats.…”
Section: Resultscontrasting
confidence: 57%
“…These results conflict with previously published observations of Odell (7), who reported finding no significant difference in the urea and nonurea solute concentrations of the inner medulla in weanling jj and Jj rats and concluded that jaundiced weanling jj rats up to 21 days of age have normal medullary function. However, Odell (7) did not determine urine osmolality in the two groups of animals, which would have been a more sensitive method of estimating urine concentrating ability, and this may explain, at least in part, his failure to detect a defect in U.as in the jaundiced weanling jj rats. Possibly of equal importance in explaining the discrepancy in results between the two studies is the fact that the solute analyses were performed on the entire inner medulla, not just the papillary tip (7).…”
Section: Resultscontrasting
confidence: 57%
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