The response of hippocampal functional connectivity to sustained pain in a pain-sensitive population

Tang, Yingjie; Duan, Mingjun; Tan, Saiying; Liu, Xiaoli; Yao, Dezhong; Chen, Luo; He, Hong

doi:10.1080/27706710.2023.2185105

Cited by 2 publications

(2 citation statements)

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“…Functional connectivity (FC) captures the statistical dependence or temporal correlations between different regions 14,15 . The blood oxygen level‐dependent signal was previously known to reflect neural activity primarily in the gray matter, thus previous studies investigated FC between gray‐matter networks.…”

Section: Introductionmentioning

confidence: 99%

“…Functional connectivity (FC) captures the statistical dependence or temporal correlations between different regions. 14 , 15 The blood oxygen level‐dependent signal was previously known to reflect neural activity primarily in the gray matter, thus previous studies investigated FC between gray‐matter networks. In recent years, more and more attention has been paid to the functional characteristics of white matter.…”

Section: Introductionmentioning

confidence: 99%

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Brain activation and connection across resting and motor‐task states in patients with generalized tonic–clonic seizures

Jiang,

Wang,

Pei

et al. 2024

CNS Neurosci Ther

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AimsMotor abnormalities have been identified as one common symptom in patients with generalized tonic–clonic seizures (GTCS) inspiring us to explore the disease in a motor execution condition, which might provide novel insight into the pathomechanism.MethodsResting‐state and motor‐task fMRI data were collected from 50 patients with GTCS, including 18 patients newly diagnosed without antiepileptic drugs (ND_GTCS) and 32 patients receiving antiepileptic drugs (AEDs_GTCS). Motor activation and its association with head motion and cerebral gradients were assessed. Whole‐brain network connectivity across resting and motor states was further calculated and compared between groups.ResultsAll patients showed over‐activation in the postcentral gyrus and the ND_GTCS showed decreased activation in putamen. Specifically, activation maps of ND_GTCS showed an abnormal correlation with head motion and cerebral gradient. Moreover, we detected altered functional network connectivity in patients within states and across resting and motor states by using repeated‐measures analysis of variance. Patients did not show abnormal connectivity in the resting state, while distributed abnormal connectivity in the motor‐task state. Decreased across‐state network connectivity was also found in all patients.ConclusionConvergent findings suggested the over‐response of activation and connection of the brain to motor execution in GTCS, providing new clues to uncover motor susceptibility underlying the disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%