The response of gastric stretch receptors and certain other abdominal and thoracic vagal receptors to some drugs

Paintal, A. S.

doi:10.1113/jphysiol.1954.sp005208

Cited by 71 publications

(21 citation statements)

References 12 publications

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“…A. S. PAINTAL Injection of 2 ml. 1-2% KCl into the abdominal aorta stimulated five out of eight gastric stretch receptors; the resulting responses resembled those following injection of phenyl diguanide (see Paintal, 1954b) Fig. 11.…”

Section: Initiation Of Sensory Dischargesmentioning

confidence: 71%

The influence of certain chemical substances on the initiation of sensory discharges in pulmonary and gastric stretch receptors and atrial receptors

Paintal¹

1957

The Journal of Physiology

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Section: Initiation Of Sensory Dischargesmentioning

confidence: 71%

The influence of certain chemical substances on the initiation of sensory discharges in pulmonary and gastric stretch receptors and atrial receptors

Paintal¹

1957

The Journal of Physiology

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“…Since then these gastric stretch receptors have been studied further, and several interesting facts regarding their responses to mechanical stimuli and drugs have emerged. Their responses to drugs are described in another paper (Paintal, 1954b).…”

mentioning

confidence: 99%

A study of gastric stretch receptors. Their role in the peripheral mechanism of satiation of hunger and thirst

Paintal¹

1954

The Journal of Physiology

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242

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“…This has been shown for acetylcholine (Coon & Rothman, 1940;Brown & Gray, 1948;Riker, 1958;Fjallbrant & Iggo, 1961;Lim, Guzman & Rodgers, 1961;Keele & Armstrong, 1964), for 5-hydroxytryptamine (Paintal, 1954;McCubbin, Green, Salmoiraghi & Page, 1956;Fjallbrant & Iggo, 1961;Skinner & Whelan, 1962;Keele & Armstrong, 1964), for bradykinin (Fjallbrant & Iggo, 1961;Lim et al, 1961;Keele & Armstrong, 1964;Blane, 1967), for phenyldiguanide (Paintal, 1954;Karczewski & Widdicombe, 1969) and for histamine (Fjiillbrant & Iggo, 1961;Keele & Armstrong, 1964;Karczewski & Widdicombe, 1969).…”

Section: Discussionmentioning

confidence: 99%

A study of compounds which initiate and block nerve impulses in the perfused rabbit liver

Andrews

Orbach

1973

British J Pharmacology

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Summary1. A technique for the perfusion of the rabbit liver with Krebs solution is described: the hepatic nerves were monitored for centripetal action potentials. Spontaneous afferent activity, and a good response to stimulating agents persisted for 7 h or longer. 2. Action potentials were elicited by injections or infusions of acetylcholine, 5-hydroxytryptamine, bradykinin, phenyldiguanide, adrenaline and various other compounds. From comparison with experiments carried out in vivo by other authors, it would appear that most of the nerves stimulated were afferent. 3. Inhibition of action potentials, either those occurring spontaneously or those elicited by injections, was produced by aspirin, paracetamol, mepyramine, chlorpheniramine, procaine and lignocaine but not by morphine or atropine. Pentolinium produced some inhibition, as did hexamethonium in concentrations of about 7-5 ,ug/ml. 4. Three methods for using the preparation for the assessment of local anaesthetic action are described. 5. Lobeline, potassium cyanide and 2,4-dinitrophenol stimulated nerve bundles which were not stimulated by anoxia or hypoxia. IntroductionIn the study reported here, various substances were injected into the portal vein while the hepatic nerves were monitored for centripetal action potentials. The object of the experiments was to obtain some indication of how many different types of nerve fibre are present in the rabbit liver and also to try to determine whether the elicited action potentials were in afferent nerves or whether they were antidromic and originated from stimulation of motor nerve terminals. Although the work was begun as an investigation of hepatic nerves, it soon became apparent that the perfused liver is a useful preparation for the study of actions and interactions of various substances on afferent nerve endings, and can also be used to test whether a compound possesses a local anaesthetic action. The innervation of the liver is profuse (Sutherland, 1964) and several different types of nerve receptors

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The response of gastric stretch receptors and certain other abdominal and thoracic vagal receptors to some drugs

Cited by 71 publications

References 12 publications

The influence of certain chemical substances on the initiation of sensory discharges in pulmonary and gastric stretch receptors and atrial receptors

The influence of certain chemical substances on the initiation of sensory discharges in pulmonary and gastric stretch receptors and atrial receptors

A study of gastric stretch receptors. Their role in the peripheral mechanism of satiation of hunger and thirst

A study of compounds which initiate and block nerve impulses in the perfused rabbit liver

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