The response of female urogenital tract epithelia to mesenchymal inductors is restricted by the germ layer origin of the epithelium: prostatic inductions

Boutin, Eugenie L.; Battle, Ella; Cunha, Gerald R.

doi:10.1111/j.1432-0436.1991.tb00248.x

Cited by 36 publications

(29 citation statements)

References 29 publications

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“…A number of morphological, histochemical, and immunohistochemical markers distinguish these epithelia (Forsberg, 1962;Olivecrona, 1964, 1965;Forsberg and Nord, 1969;Forsberg and Kvinnsland, 1972). In addition, Mullerian and sinus vaginal epithelia differ in their proliferative rate (Forsberg, 1965b) and in their competence to respond to heterotypic mesenchymal inductors (Boutin et al, 1991a(Boutin et al, , 1992. The latter especially speaks to the different germ layer origin of the two epithelia.…”

Section: Discussionmentioning

confidence: 95%

Does sinus vaginal epithelium persist in the adult mouse vagina?

Boutin

Cunha

1996

Dev. Dyn.

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Section: Discussionmentioning

confidence: 95%

Does sinus vaginal epithelium persist in the adult mouse vagina?

Boutin

Cunha

1996

Dev. Dyn.

Self Cite

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“…In the UGS, mesenchymal cells express androgen receptors and act under the influence of androgens to induce prostatic differentiation of the endodermal epithelium (2,3). Tissue recombination experiments have shown that the mesenchyme is the primary determinant of epithelial growth and differentiation (4).…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line

et al. 2006

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“…The immunohistochemical localisation of the AR shows characteristic differences between the epithelial components in the junctional zone indicating irreversibly different states of determination as shown by Boutin et al [1991]. The Müllerian epithelium is completely devoid of AR.…”

Section: Localisation Of Armentioning

confidence: 96%

Helper Function of the Wolffian Ducts and Role of Androgens in the Development of the Vagina

Drews¹

2007

Sex Dev

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The development of a vagina as a separate outlet of the birth canal evolves at the transition of egg laying species to eutherian mammals. The derivation of the vagina from the Wolffian and Müllerian ducts and the contribution of the urogenital sinus are still open questions. Here experiments with the complete androgen receptor defect in the testicular feminisation (Tfm) mouse are reported which show that the vagina is formed by caudal migration of Wolffian and Müllerian ducts. The cranial ends of the Wolffian ducts successively regress while the Müllerian ducts fuse to form the vagina. Immunohistochemistry of the androgen receptor reveals that the caudal ends of the Wolffian ducts remain in the indifferent stage and therefore have been mistaken as sinuvaginal bulbs. The Wolffian ducts do not contribute to the vagina itself but have a helper function during downward movement of the vaginal bud in the female. In the male the caudal ends serve as androgen operated switch for the negative control of vaginal development. The results indicate that the rudimentary vagina in the complete androgen insensitivity syndrome (CAIS) corresponds to non obliterated caudal ends of the Müllerian ducts. Selective atresia of the vagina in the MRKH (Mayer-Rokitansky-Küster-Hauser) syndrome may be explained by the failure of Wolffian and Müllerian ducts to descend caudally.

show abstract

The response of female urogenital tract epithelia to mesenchymal inductors is restricted by the germ layer origin of the epithelium: prostatic inductions

Cited by 36 publications

References 29 publications

Does sinus vaginal epithelium persist in the adult mouse vagina?

Does sinus vaginal epithelium persist in the adult mouse vagina?

Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line

Helper Function of the Wolffian Ducts and Role of Androgens in the Development of the Vagina

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