“…Theoretically, the incretin effect of GLP-1, as well as ghrelin, would have an anabolic effect on metabolism [325,385], whereas higher circulating levels of PYY increase fatty acid oxidation and decrease energy efficiency [375]. A diet high in protein at the expense of carbohydrate would furthermore translate into a higher glucagon:insulin ratio, known to increase intracellular levels of cAMP in both liver and adipose tissue [408][409][410][411]. SREBPs/LXR↑↑ SREBPs/LXR↑ [189,190] ChREBP↑↑ ChREBP↑ [197] Fructose Unclear Increased Unclear [67,68] Fatty acids Saturated fatty acids Stimulation Increased [24,180,[399][400][401][402][403][404] All PPARs↑ [121][122][123][124]180] n-3 PUFAs Inhibition Decreased [23,29,137,[420][421][422][423][424][425][426] PPARα↑↑↑ PPARα↑↑↑ [121,124,130,180] PPARγ↓ PPARγ↓ [166][167][168][169]180] SREBPs/LXR↓↓ SREBPs/LXR↓↓ …”