The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

Hussell, Tracy; Isaacson, Peter G.; Crabtree, Jean E.; Spencer, Jo

doi:10.1016/0140-6736(93)91408-e

Cited by 731 publications

(346 citation statements)

References 18 publications

Supporting

Mentioning

316

Contrasting

Unclassified

Order By: Relevance

“…The organism induces T cell IL-2 receptor expression and secretion of IL-2, an activity that is eliminated if T cells are removed [55]. CD4 + T cells predominate in MALT lymphomas, the majority of which bear the CD45RO, a marker for memory T cells [56].…”

Section: Discussionmentioning

confidence: 99%

“…In patients who fail or are not candidates for local therapy, an optimal treatment program has not been de®ned. Fludarabine, which has excellent activity in many small-cell lymphomas, has a profound and prolonged inhibitory e ect on T cell function [55] and might be particularly toxic in CVID patients. On the other hand, Rituximab, the monoclonal antibody directed against the pan B cell antigen CD20, might be an attractive treatment option as it would not substantially worsen the severity of immunosuppression and is highly active in other B cell lymphomas; this treatment was used in cases 4 and 5.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lymphomas of mucosal‐associated lymphoid tissue in common variable immunodeficiency

et al. 2002

View full text Add to dashboard Cite

Common variable immunode®ciency (CVID) is a primary immunode®ciency disease characterized by low serum immunoglobulins IgG, IgA, and usually IgM. The central immune de®ciency is impaired secretion of immunoglobulins and lack of antibody production; however, T cell dysfunction and a variety of in¯ammatory complications suggest global immune dysregulation. A number of reports have documented the association of primary immunode®ciency diseases with the development of non-Hodgkin's lymphoma (NHL). In CVID, the risk has been estimated to lie between 1.4% and 7%. As for NHL arising in other immunode®ciency states, the lymphomas in CVID are extranodal and are usually B cell in type. Of 22 B cell lymphomas that have appeared over a period of 25 years in a cohort of subjects with CVID, ®ve lymphomas, appearing in more recently studied subjects, that arose in mucosal sites would be classi®ed as mucosaassociated lymphoid tissue (MALT) lymphomas. MALT lymphomas are low-grade B cell lymphomas that result from a proliferation of neoplastic marginal-zone related cells of lymphoid tissue and tend to occur in organs that have acquired lymphoid tissue due to long-term infectious or autoimmune stimulation. Lymphomas of this kind have not been described in patients with congenital immunode®ciency, although chronic mucosal antigen stimulation is an integral part of these immune de®ciency states. Am.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lymphomas of mucosal‐associated lymphoid tissue in common variable immunodeficiency

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Such an association might help to explain the development of lymphoid malignancies associated with chronic antigenic stimulation seen in a variety of conditions such as Helicobacter related peptic ulcer (Hussell et al, 1993), Lyme disease (Garbe et al, 1991), Sjoegren's syndrome (Pavlidis et al, 1992), Hashimoto's thyroiditis (Isaacson, 1993) and Castleman's disease (Soulier et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Chromosomal translocations deregulating c-myc are associated with normal immune responses

et al. 1997

View full text Add to dashboard Cite

Plasmacytomas induced in BALB/c mice by pristane consistently evidence chromosomal translocations involving the c-myc gene and one of the Ig loci. This observation has lead to the suggestion that c-myc deregulation is a critical event in the generation of such tumors. However, it is not clear whether c-myc translocation is related to pristane treatment or occurs in normal lymphocyte populations nor whether such translocations occur normally, and at similar frequencies, in strains genetically resistant to plasmacytoma development, such as DBA/2. In order to address these questions, a Long Distance PCR assay with single copy sensitivity was employed to assess the frequency of cmyc/IgA translocations in normal and immunized mice of both plasmacytoma resistant and susceptible lineages in the absence of pristane treatment. Our data demonstrate that spontaneous translocations occur in normal DBA/2 and BALB/c mice with no signi®cant di erences in frequency. A 3 ± 5-fold increase in translocation frequency was observed in mice immunized with cholera toxin, a strong stimulator of IgA responses. We conclude that c-myc deregulation by chromosomal translocation is associated with normal physiological processes of B-cell di erentiation and, as such, can not be the determining factor leading to malignancy.

show abstract

“…13 Nevertheless, in this subset of EMZL, tumor immunoglobulins seem to be autoantigen-related rather than specific to H. pylori and the neoplastic growth seem to be sustained by stimulation through a H. pylori-specific T-cell reaction. 49,50 We cannot exclude that HCV could play a role similar to that of H. pylori in gastric EMZL in the subset of HCV-positive NMZL.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma

Marasca

Vaccari

Luppi

et al. 2001

The American Journal of Pathology

137

View full text Add to dashboard Cite

show abstract

The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

Cited by 731 publications

References 18 publications

Lymphomas of mucosal‐associated lymphoid tissue in common variable immunodeficiency

Lymphomas of mucosal‐associated lymphoid tissue in common variable immunodeficiency

Chromosomal translocations deregulating c-myc are associated with normal immune responses

Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma

Contact Info

Product

Resources

About