The response of breeding does to nematodiasis: Segregation into “Responders” and “non-responders”

Patterson, D. M.; Jackson, F.; Huntley, J.F.; Stevenson, L.M.; Jones, Douglas; Jackson, Elizabeth B.; Russel, A.J.F.

doi:10.1016/s0020-7519(96)00125-7

Cited by 35 publications

(19 citation statements)

References 31 publications

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“…These values of repeatability coefficients measured for egg counts in dairy goats (0.25 and 0.30) are close to those mentioned in Cashmere male (0.31) or female (0.19) goats [53,54] and Angora goats [74]. In addition, repeatabilities calculated between years were also relatively high.…”

Section: Repeatability Of Infectionsupporting

confidence: 84%

Control of gastrointestinal parasitism with nematodes in dairy goats by treating the host category at risk

Hoste¹,

Chartier

Frileux

2002

Vet. Res.

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-Infections of the gastrointestinal tract with parasitic nematodes remain one of the main limiting factors in grazing dairy goats. The usual mode of control of these parasitic diseases has up to now been based on the repeated use of anthelmintics. However, the prevalence rates of anthelmintic resistances, in particular to benzimidazoles, are now particularly high in the French dairy goat production. This situation makes it mandatory to reconsider the usual mode of control of these nematodes and to look for short term, alternative solutions which combine the control of gastrointestinal infections and management of anthelmintic resistances. One of the possible options is to leave a part of the flock without treatment during the grazing season in order to maintain alleles of susceptibility to anthelmintics within the worm populations. Previous epidemiological observations identifying the categories of host populations at risk are presented which provide the rationale for targeted applications of treatments. The results of assays on experimental flocks and from farm surveys examining the advantages and drawbacks of selective treatments are presented. The value of these results in combination with other alternative solutions of control are discussed in order to use minimum treatments with maximum benefits. dairy goat / anthelmintic / selective treatment / anthelmintic resistance / parasitic nematode Résumé -Maîtrise des strongyloses gastro intestinales chez les chèvres laitières par l'application de traitements ciblés. Les infestations par les nématodes du tractus gastro intestinal demeurent un des principaux facteurs limitant à l'élevage des chèvres laitières au pâturage. Le mode usuel de maîtrise de ce parasitisme reposait jusqu'à présent sur un usage répété de molécules anthelminthiques. Cependant, la prévalence des lignées résistantes aux anthelminthiques, en particulier aux benzimidazoles, en éle-vage caprin laitier en France, est désormais très élevée. Ce constat oblige à rechercher rapidement des 531

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Section: Repeatability Of Infectionsupporting

confidence: 84%

Control of gastrointestinal parasitism with nematodes in dairy goats by treating the host category at risk

Hoste¹,

Chartier

Frileux

2002

Vet. Res.

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“…An increase in the number of mucosal mast cells and globule leukocytes has previously been mentioned in does showing an enhanced resistance against T. circumcincta and Trichostrongylus vitrinus (Patterson et al, 1996a). Etter et al (2000) have observed a negative correlation between egg production from T. colubriformis and the number of intestinal globule leukocytes.…”

Section: Discussionmentioning

confidence: 68%

Effects of condensed tannins on goats experimentally infected with Haemonchus contortus

Paolini

Bergeaud

Grisez

et al. 2003

Veterinary Parasitology

167

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Although the use of tanniferous plants or condensed tannins as an alternative to anthelmintics to control gastrointestinal nematodes has been largely documented in sheep, studies remain scarce in goats. The objective of this study was therefore to assess the possible impact of condensed tannins in goats infected with adult Haemonchus contortus. Two groups of cull goats were experimentally infected with 10.000 L3 of H. contortus. After 4 weeks, quebracho extracts, representing 5% of the diet DM, were administered for 8 days to one of the two groups. Goats of the second group remained as controls. One week after the end of quebracho administration, the goats were euthanised. Individual egg excretion and pathophysiological parameters were measured weekly during the study. At the end of the study, worm counts were assessed and histological samples from the abomasa were taken to count the numbers of mucosal mast cells, globule leukocytes and eosinophils. The administration of tannins was associated with a significant decrease in egg excretion, which persisted until the end of experiment. This reduction was not associated with any difference in worm number but with a significant decrease in female fecundity. No significant changes in the mucosal density of the three inflammatory cell types were detected between the two groups. These results indicate that the major consequence of tannin consumption in goats is a reduction in worm fecundity and egg output, which does not seem related to significant changes in the local mucosal response.

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“…Significant increases in the number of blood eosinophil cells were observed only in the HP group. According to Dawkins et al [12], Buddle et al [5] and Kyriazakis et al [17] for T. colubriformis infected sheep or Patterson et al [18,19] for infected goats, a rise in blood eosinophils is associated with the immune responsiveness of the animals to parasites. Hence, in the current study, the HP diet appeared to allow a better expression of the immune response in the infected goats.…”

Section: Discussionmentioning

confidence: 99%

The effect of two levels of dietary protein on resistance and resilience of dairy goats experimentally infected with Trichostrongylus colubriformis: comparison between high and low producers

et al. 2000

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-Numerous studies have examined the interactions between protein nutrition and the response to nematode parasitism in sheep, but very few in goats. Compared with other ruminants, goats are less resistant to nematode infection. In addition, in dairy goats, high producing animals have been shown to be less resistant and less resilient to infection compared to low producing ones. The objective of the present study was to examine the consequences of protein supplementation on both resistance and resilience of dairy goats to nematode trickle infection, taking into account the initial level of milk production of the animals. During a 14-week period, 40 milking goats received a high protein (HP) diet supplying 130% of the protein requirements, and 38 goats were fed a intermediate protein (IP) diet (120% of the protein requirements). In addition, half of each group was given a weekly trickle infection with Trichostrongylus colubriformis larvae, the other part of the flock remained non-infected. Faecal egg counts (FEC), eosinophil counts and pathophysiological data (urea, albumin and inorganic phosphate concentrations in the serum) were measured twice a month. Milk production data (milk yield, protein and fat contents) were also recorded every 15 days. The results showed that FECs were lower (p < 0.05) and eosinophil counts higher (p < 0.05) in the animals receiving the HP diet suggesting that resistance was enhanced by protein supplementation. Meanwhile, milk parameters (related to resilience) were not affected by the level of protein in the diet when considering the whole groups. In contrast, in the high producing goats, the milk production and milk composition parameters were improved with the HP diet. To conclude, we have seen that the expression Vet. Res. 31 (2000) 247-258 247

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The response of breeding does to nematodiasis: Segregation into “Responders” and “non-responders”

Cited by 35 publications

References 31 publications

Control of gastrointestinal parasitism with nematodes in dairy goats by treating the host category at risk

Control of gastrointestinal parasitism with nematodes in dairy goats by treating the host category at risk

Effects of condensed tannins on goats experimentally infected with Haemonchus contortus

The effect of two levels of dietary protein on resistance and resilience of dairy goats experimentally infected with Trichostrongylus colubriformis: comparison between high and low producers

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