The Response and Tolerability of a Novel Cold Atmospheric Plasma Wound Dressing for the Healing of Split Skin Graft Donor Sites: A Controlled Pilot Study

Welzen, A van; Wahl, Philip; Weber, Frank; Rode, Susen; Tietze, Julia K.; Boeckmann, Lars; Emmert, Steffen; Thiem, Alexander

doi:10.1159/000517524

Cited by 22 publications

(21 citation statements)

References 50 publications

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“…Characteristics of included studies are presented in Table 1. Eight studies [12][13][14][15][16][17][18][19][20] were conducted in Germany, three in Iran [21][22][23], one in Austria [24], and one in Thailand [20]. The 13 included studies involved a total of 477 participants, who were randomized either into CAP treatment group or control group.…”

Section: Generalmentioning

confidence: 99%

Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds: An Updated Systematic Review and Meta-Analysis of RCTs

Julan

Huang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. A previous meta-analysis has revealed that cold atmospheric plasma (CAP) might not be clinically beneficial to chronic wounds. However, several new randomized controlled trials (RCTs) reported that CAP was an effective treatment option for accelerating wound healing in chronic wounds. The purpose of this review is to incorporate these new results and evaluate the efficacy of CAP in chronic wounds. Methods. The major databases, including PubMed, Embase, Cochrane Library, and Web of Science, were searched for articles related to CAP treatment in chronic wounds until March 21, 2022. The literature retrieval and evaluation were carried out by two independent researchers. Result. A total of 13 randomized clinical trials published between 2010 and 2022 were finally included. CAP therapy showed to be more effective in reducing the area of wounds (mean difference (MD): -1.74, 95%; confidence interval (CI): [-3.14, -0.33], p = 0.02 ), compared with non-CAP treatments. The immediate reduction of the bacterial load was higher in the CAP group than in the control group. (MD: -0.37, 95%; CI: [-0.7, -0.05], p = 0.02 ). Conclusion. No significant changes were found in long-term antibacterial efficacy and pain perception between the two groups. However, more RCTs of excellent methodological quality are required to confirm technical details of the source of AP and the appropriate duration of the treatment with plasma.

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Section: Generalmentioning

confidence: 99%

Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds: An Updated Systematic Review and Meta-Analysis of RCTs

Julan

Huang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…[33][34][35] CAP offers a new noninvasive, selective targeting therapy to biological tissue at the molecular level with various applications in dermatology. [36][37][38][39] It can potentially improve and normalize the wound healing process. 40,41 Short plasma treatment times/low plasma does have stimulating effects by increasing proliferation and migration and induction of DNA repair.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of keloid: A randomized controlled trial

Suwanchinda

Nararatwanchai

2022

J of Cosmetic Dermatology

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Background Keloid (KD) treatment is challenging for both physicians and patients. It can be functional debilitating and psychologically distressing. Available current therapeutics modalities give inconsistently effective results. Objectives To evaluate the efficacy and safety of innovative cold atmospheric plasma (CAP) technology in the treatment of keloid. Methods This prospective, randomized control trial, the assessor‐blinded trial, includes 18 patients with keloids. The keloid lesion was divided into two halves. One side was randomly treated with CAP technology biweekly on the same treated side for five sessions with a follow‐up 30 days after finishing the final treatment. Another half was left untreated as a control. Efficacy assessment using POSAS, VSS, Patients' satisfaction scale, Antera 3D® skin imaging system. The safety assessment using VAS and adverse effects monitoring was completed. Results Objective assessment using Antera 3D® skin imaging system (Miravex, Dublin, Ireland) showed statistically significant improvement (p‐value <0.05) on the treated side compared with the untreated side in all parameters, color, melanin, hemoglobin, texture, except for volume. POSAS, patient, and observer overall opinion score, and patient and observer total score in the summary of all rated characteristics, comparing the treated and untreated areas, showed a statistically significant reduction in all parameters after two treatments (*p‐value <0.05). VSS showed statistically significant improvement after the second treatment and continued to the last follow‐up. Most patients rated satisfaction scales up to 72.2% as moderate improvement, 11.1% as great improvement, 11.1% as slight improvement, and 5.6% as no change. The adverse effect was only a small scab in one patient. Conclusion CAP technology could be considered an alternative treatment for keloid offering mild‐to‐moderate improvement with minimal side effects.

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“…Cold atmospheric plasma (CAP) has already been used in dermatology. [39][40][41][42] It offers a new non-invasive, selective targeting therapy to biological tissue at the molecular level with various applications. It exhibited the potential to stimulate wound healing.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of striae distensae: A randomized controlled trial

Suwanchinda

Nararatwanchai

2022

J of Cosmetic Dermatology

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Background Available current therapeutics modalities for striae distensae (SD) provide inconsistently effective outcomes. There is ongoing research on innovative treatment modalities to find better treatment solutions. Objectives To evaluate the efficacy and safety of innovative cold atmospheric plasma (CAP) technology in the treatment of striae distensae. Methods This study includes twenty‐three patients with striae distensae. The body was divided into two halves. One side was randomly treated with CAP biweekly on the same treated side for five sessions with 30 days follow‐up after the last session. Another half was left untreated. Efficacy assessment was done using patient and observer scar assessment scale (POSAS), patient satisfaction scales, and Antera 3D® skin imaging system. Safety assessment was evaluated using the visual analog scale (VAS) and adverse effects monitoring. Results Patient and observer scar assessment scale, patient and observer overall opinion score, and patient and observer total score in a summary of all rated characteristics, comparing treated and untreated areas, showed a statistically significant reduction in all parameters after one treatment (*p‐value <0.05). Patients rated satisfaction as a great improvement in 52.3%, moderate improvement in 39.1%, extreme improvement in 4.3%, and slight improvement in 4.3%. Adverse effects included small scabs, shallow wounds, and rash. Conclusion Cold atmospheric plasma is a safe and effective, innovative treatment modality for striae distensae with minimal side effects.

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The Response and Tolerability of a Novel Cold Atmospheric Plasma Wound Dressing for the Healing of Split Skin Graft Donor Sites: A Controlled Pilot Study

Cited by 22 publications

References 50 publications

Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds: An Updated Systematic Review and Meta-Analysis of RCTs

Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds: An Updated Systematic Review and Meta-Analysis of RCTs

Efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of keloid: A randomized controlled trial

The efficacy and safety of the innovative cold atmospheric‐pressure plasma technology in the treatment of striae distensae: A randomized controlled trial

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