The Respiratory System

Gould, Steve

doi:10.1007/978-1-84628-743-5_20

Cited by 6 publications

(1 citation statement)

References 218 publications

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“…Mechanisms impairing these processes cause lung hypoplasia and it might be expected that in the current case, the site of the hamartoma would have prevented both normal closure of the larynx, allowing increased egress of lung fluid and, through a ball-valve effect, impeded any ingress of fluid and lung expansion occurring during normal breathing movements. 6 It is this lung expansion, which is thought to be important in maintaining normal lung growth. 7…”

Section: Discussionmentioning

confidence: 99%

Laryngeal hamartoma causing polyhydramnios and lethal pulmonary hypoplasia

Webb¹,

Richmond²,

Wright³

et al. 2010

Aust NZ J Obst Gynaeco

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Section: Discussionmentioning

confidence: 99%

Laryngeal hamartoma causing polyhydramnios and lethal pulmonary hypoplasia

Webb¹,

Richmond²,

Wright³

et al. 2010

Aust NZ J Obst Gynaeco

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Caso congénito de citomegalovirus en el Hospital San Ignacio

Espinosa

Contreras

2010

Univ. Med.

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ResumenLas infecciones ocurridas durante la gestación son una importante preocupación, tanto por su incidencia como por las consecuencias de secuelas y muerte que pueden traer para el recién nacido. Sin embargo, la sospecha clínica de infección por citomegalovirus en obstetricia y en pediatría no se correlaciona con la baja confirmación que se hace de la enfermedad.En la placenta, la infección congénita por citomegalovirus (CMV) se refleja en la aparición de villitis crónica, la cual se caracteriza por infiltrado inflamatorio linfohistiocitario focal o difuso en las vellosidades. De estos casos, 80% son asintomáticos y los que tienen síntomas presentan graves déficits neurológicos, retardo del crecimiento intrauterino e, incluso, la muerte. En autopsias fetales, la presencia de inclusiones típicas por citomegalovirus hace el diagnóstico de infección por CMV.Se presenta el caso de un óbito fetal, producto del primer embarazo de una madre adolescente sin adecuado control prenatal, y en cuya autopsia se documentó villositis crónica y la presencia de inclusiones virales en múltiples órganos, tales como vías aéreas y páncreas, con confirmación por inmunohistoquímica.Palabras clave: infección congénita, citomegalovirus, villositis crónica. AbstractInfections during pregnancy are a major concern bothdue to its incidence and sequelae it might carry, including death. However, clinical suspicion of cytomegalic infection in obstetrics and pediatrics does not correlate with the low confirmation of the disease.

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Molecular and Physiological Determinants of Pulmonary Developmental Biology: a Review

Hameed¹,

Sherkheli²,

Hussain³

et al. 2013

AJBR

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The lungs undergo an extensive endodermal diverging morphogenesis along with alveogenesis, angiogenesis, and vasculogenesis to secure a sufficient diffusion surface for gaseous exchange. Any aberration in the course of normal development inculcating structural and functional abnormalities of lungs in antenatal life has potential morbidity in adult life. Factors such as IUGR, nutrient deficiency, FLM, Hypoxemia, ETS, surfactant deficiency, allergy and infections can adversely affect in-utero lungs development. Peculiar local and systemic inflammatory immune responses may elicit persistent architectural and physiological abnormalities. Lung surfactant produced by AEC-II cells is a mixture of phospholipids, surfactant proteins, and neutral lipids. Surfactant lowers alveolar surface tension, a crucial step for the prevention of alveolar collapse. Surfactant proteins are part of the innate immune defense of the lung. Surfactant deficiency and dysfunction is known to implicate a number of respiratory diseases especially allergic asthma and NRDS. The present article provides a state of the art review of the current knowledge of biology of normal lung development, its anatomical and molecular aspects, factors that regulate normal organogenesis of pulmonary system and molecular basis of respiratory allergic disorders including asthma.

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The Respiratory System

Cited by 6 publications

References 218 publications

Laryngeal hamartoma causing polyhydramnios and lethal pulmonary hypoplasia

Laryngeal hamartoma causing polyhydramnios and lethal pulmonary hypoplasia

Caso congénito de citomegalovirus en el Hospital San Ignacio

Molecular and Physiological Determinants of Pulmonary Developmental Biology: a Review

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