The Resolution of Alcohols

Abstract

The resolution of nearly one hundred and fifty alcohols and phenols are recorded in the literature. Practically every known method of resolution has been applied to these classes of substances and several methods of considerable utility have been developed. This chapter gives a description and evaluation of results obtained to date. A brief statement of the underlying principles and the main steps of the procedure for all the important methods of resolution are included.

Practical method for increasing optical purity of cis‐verbenol

“…In our approach, crude verbenol ( S )‐ 1 was converted into phthalic mono ‐ester ( S )‐ 3 by treatment with phthalic anhydride. Installed carboxylic function served to obtain the salts with chiral bases. It was fortunate that cheapest ( R )‐α‐methylbenzylamine and ( S )‐α‐methylbenzylamine gave diastereomeric products with a completely different crystallization behavior (Scheme ).…”