The research progresses and future prospects of Tetrastigma hemsleyanum Diels et Gilg: A valuable Chinese herbal medicine

Hu, Wenjing; Zheng, Yujie; Xia, Pengguo; Liang, Zongsuo

doi:10.1016/j.jep.2021.113836

Cited by 43 publications

(24 citation statements)

References 23 publications

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“…In traditional Chinese medicine, there is no clear record of CAG disease name, but according to the symptoms and signs of CAG, TCM attributed it to “epigastric pain” and “gastric ruffian” belonging to the category of spleen and stomach diseases which can be caused by factors of dietary and emotional disorders [ 13 ]. As a result, clinical treatment should be carried out to resolve phlegm, eliminate stasis, regulate qi, and harmonize the stomach [ 14 ]. Rhizoma phragmitis and Rhizoma curcumae play important roles in the treatment of chronic atrophic gastritis [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

A Web-Based Pharmacological Approach to the Mechanism of Action of Rhizoma Phragmitis and Rhizoma Curcumae in the Treatment of Chronic Atrophic Gastritis

Zhi

Xie

Shao

et al. 2022

Contrast Media & Molecular Imaging

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Objective. To analyze and test the effect of Rhizoma phragmitis and Rhizoma curcumae on the network pharmacology of MAPK (mitogen-activated protein kinase) and TNF (tumor necrosis factor) signaling channels and inflammatory factor target gene regulation in successful modeling of chronic atrophic gastritis rats. Methods. Rats with chronic atrophic gastritis that were modeled successfully were randomly divided into control and study groups and were treated with conventional western medicine or Rhizoma phragmitis and Rhizoma curcumae, respectively. The pharmacological mechanism of action and efficacy were evaluated. Results. The treatment efficiency was 76.32% and 97.37% in the control and study group, respectively. After treatment, the serum tumor necrosis factor-α (TNF-α) and serum malondialdehyde (MDA) levels in the study group were lower than those in the control group and the serum epidermal growth factor (EGF) and superoxide dismutase (SOD) levels in the study group were higher than those in the control group (P < 0.05); the pain behavioral scores in the study group were lower than those in the control group, and the free acid quantity and total acid quantity in the study group were higher than those in the control group (P < 0.05); the serum MTL index in the study group was higher than that in the control group, and the serum gastrin (GAS) and pepsinogen I (PG I) indices in the study group were lower than those in the control group (P < 0.05); the number of 24-hour reflux in the study group was less than that in the control group (P < 0.05), and the longest reflux time in the study group was lower than that in the control group (P < 0.05). Conclusion. Based on the network pharmacological results, Rhizoma phragmitis and Rhizoma curcumae will modulate MAPK, TNF signaling circuits, and inflammatory factor target genes in the chronic atrophic gastritis rat model. This treatment protocol is efficient and beneficial to enhance the gastric function of the chronic atrophic gastritis rat model, while it can alleviate the inflammatory response and significantly reduce the number and duration of reflux, which is a safe and reliable treatment modality.

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Section: Discussionmentioning

confidence: 99%

A Web-Based Pharmacological Approach to the Mechanism of Action of Rhizoma Phragmitis and Rhizoma Curcumae in the Treatment of Chronic Atrophic Gastritis

Zhi

Xie

Shao

et al. 2022

Contrast Media & Molecular Imaging

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“…In addition, there was no remarkable interference at the retention time of the analytes in the blank solvent (Figure S2), indicating that the method was specific. The results (Table 3) showed that all the 42 reference com- T A B L E 3 Linearity, limit of detection (LOD) and limit of quantification (LOQ) data of the 42 analytes 6 1.0000 2.60-650.00 0.42 1.75 y = 8.183e 3 x À 3.399e 4 0.9993 10.00-250.00 1.21 4.15 y = 1.065e 3 x + 6.293e 3 0.9987 10.00-250.00 1.59 5.26 y = 2.846e 5 x + 7.304e 4 1.0000 2.36-118.00 0.12 0.39 y = 5.172e 1 x + 9.171e 2 0.9984 16.40-820.00 0.92 2.80 y = 6.319e 5 x À 1.114e 5 0.9997 2.33-116.00 0.09 0.30 y = 1.448e 5 x + 5.605e 5 0.9997 10.00-500.00 0.38 1.27 y = 5.996e 4 x + 1.634e 4 1.0000 10.00-250.00 0.26 0.87 y = 1.422e 4 x + 2.057e 4 1.0000 10.00-500.00 0.85 2.83 y = 7.043e S1 The results (Figure 2 and Table S1) showed that there were significant differences among the contents of the 42 analytes in the different parts of T. hemsleyanum. For example, isoorientin (5), a flavonoid C-glycoside with anti-inflammatory and antioxidant activities, was the highest component among the 42 analytes in LTH (3030.55 μg/g), which was more than STH (1229.88 μg/g, P < 0.01) and RTH (488.28 μg/g, P < 0.01).…”

Section: Methods Validationmentioning

confidence: 99%

“…(1), lucenin-2 (2), epicatechin (3), orientin-2 00 -O-β-L-galactoside (4), isoorientin (5), orientin (6), vitexin-2 00 -O-rhamnoside (7), rutin (8), vitexin (9), resveratrol (10), polydatin (11), isoquercitrin (12), astragalin (13), quercitrin (14), quercetin (15), apigenin (16), kaempferol (17), thymidine ( 18), 2 0 -deoxyuridine (19), hypoxanthine (20), allopurinol (21), isoleucine (22), leucine (23), guanine (24), 2 0 -deoxyadenosine (25), threonine (26), phenylalanine (27), valine (28), adenine (29), inosine (30), adenosine (31), proline (32), tyrosine (33), alanine (34), glycine (35), cytidine (36)…”

Section: Chemicals Reagents and Materialsmentioning

confidence: 99%

“…Meanwhile, RTH was the main ingredient of Huashi Xuanfei Mixture, which has been approved by Zhejiang Provincial Drug Administration (No. Z20200026000) for clinical treatment of Corona Virus Disease 2019 (COVID‐19) 5 …”

Section: Introductionmentioning

confidence: 99%

“…Z20200026000) for clinical treatment of Corona Virus Disease 2019 (COVID-19). 5 In recent years, the wild resources of T. hemsleyanum have been over exploited and were on the verge of extinction due to its multiple medicinal values. It has been listed in the "preferentially protected crop germplasm resources of Zhejiang province" and "key protected wild plants list of Zhejiang Province" in 2011.…”

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confidence: 99%

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Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis

Luo

Yang

et al. 2022

Phytochemical Analysis

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Introduction The root of Tetrastigma hemsleyanum (RTH) has been widely used as a folk medicine in China. Meanwhile, its stems (STH) and leaves (LTH) are consumed as functional tea and food supplementation. Therefore, it is important to get a better understanding of the distribution of bioactive constituents in different parts of T. hemsleyanum. Objective To develop a method for quantitative analysis of multiple bioactive constituents and comparing their distribution in RTH, STH and LTH. Methods Ultra‐performance liquid chromatography triple quadrupole ion trap tandem mass spectrometry (UPLC‐QTRAP‐MS/MS) was used for the quantitative analysis. The quantitative data were further analysed by principal component analysis (PCA), hierarchical cluster analysis (HCA) and partial least squares determinant analysis (PLS‐DA). Results Forty‐two constituents in RTH, STH and LTH, including 14 flavonoids, three phenolic acids, 15 amino acids and 10 nucleosides, were quantitatively determined. The contents of flavonoids and phenolic acids in LTH were significantly higher than those in RTH and STH. While the contents of amino acids and nucleosides in LTH were less than those in RTH and STH. Multivariate statistical analysis can significantly classify and distinguish RTH, STH, and LTH. Conclusions The present method would be helpful for the quality control of T. hemsleyanum, and the results would be useful for the efficient utilisation of T. hemsleyanum in the future.

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Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway

Zhai

Sun

et al. 2022

Phytotherapy Research

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The dried root of Tetrastigma hemsleyanum Diels et Gilg is used as a traditional Chinese medicine in southern China, as a folk remedy for carcinomas and gastrointestinal diseases. The total flavonoids of T. hemsleyanum (THTF) provide its main bioactive constituents. However, the mechanisms underlying its potential activity on colorectal cancer are still unknown. Here, we investigated the antitumor effect of THTF on colorectal cancer in vitro and in vivo. It was found that THTF inhibited HCT‐116 and HT‐29 cell growth, with an IC50 of 105.60 and 140.80 μg/mL, respectively. THTF suppressed clonogenicity and promoted apoptosis in HCT‐116. In vivo, THTF (120 mg/kg) delayed tumor growth in HCT‐116 xenografts without influencing on body weight, organ pathology and indexes, and blood routine level. Mechanistically, THTF inhibited the expression of PI3K, AKT, and mTOR at the protein level and transcriptional levels. Molecular docking indicated eight compounds in THTF (kaempferol 3‐rutinoside, rutinum, isoquercitrin, L‐epicatechin, quercetin, astragalin, kaempferol 3‐sambubioside, and catechin) strongly bound with amino acid sites of PI3K and mTOR proteins, indicating a high affinity. The results suggest that THTF delayed colorectal tumor growth by inhibiting the PI3K/AKT/mTOR pathway and might be a potential candidate for colorectal cancer prevention.

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The research progresses and future prospects of Tetrastigma hemsleyanum Diels et Gilg: A valuable Chinese herbal medicine

Cited by 43 publications

References 23 publications

A Web-Based Pharmacological Approach to the Mechanism of Action of Rhizoma Phragmitis and Rhizoma Curcumae in the Treatment of Chronic Atrophic Gastritis

A Web-Based Pharmacological Approach to the Mechanism of Action of Rhizoma Phragmitis and Rhizoma Curcumae in the Treatment of Chronic Atrophic Gastritis

Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis

Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway

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