The research progress of mesenchymal stem cells in the treatment of traumatic brain injury

Abstract

Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world. It is urgent to ameliorate TBI damage and reduce the disability and case-fatality rate. Stem cell therapy is another medical revolution after drug and surgical medication. Mesenchymal stem cells (MSCs) are a class of cells with significant self-renewal and multi-lineage differentiation properties and be favorable for the treatment of various diseases and injuries, it could be envisioned that MSCs transplantation may be a promising treatment for TBI. Currently, stem cell therapy has shown promising effects in the treatment of many diseases. In this article, we will review the characteristics of MSCs, MSCs for neuronal function restoration, the properties of immune-modulatory of MSCs, and the anti-apoptotic effects of MSCs, the angiogenesis effect of MSCs,and the safety issues in MSCs therapy in TBI.

The Neuro Engraftment and Neuroregenerative effects of Hydrogen Sulphide Donor, Intracerebral MSCs, Ginko Biloba and Kefir in Attenuating Neuropathological hallmarks of Lipopolysaccharide induced Alzheimer’s disease Rat models

“…In the current study, it was also found that intraperitoneal (IP) administration of NaHS to LPS injected rats improved the cognitive abilities of the examined rats through improving spatial memory acquisition and latency time MWM. In accordance with our obtained findings, [66,67] reported that H2S plays an important crucial modulatory role in learning and memory functions by attenuating hippocampal damage and cognitive impairment in addition to protecting neurons against oxidative stress damage, neurotoxicity, and agitating apoptotic factors. It was also recorded that hydrogen sulphide down-regulates MAPK and tau protein expression in brain tissue of LPS induced rats by inhibiting Aβ production within neuron cells as a result of suppression of γ -secretase activity leading to a diminished of Aβ deposition and tangles formation with attenuating activated microglia and modulating marked antiinflammatory activity induced in the brain [68][69][70].…”

Study on umbilical cord-matrix stem cells transplantation for treatment of acute trauma brain injury in rats

“…We also observed the secretion of BDNF and glial fibrillary acidic protein (GFAP) after the therapy of MSCs. traffic in China (15,21,27). TBI includes two types in the view of pathology: limited and diffuse brain injuries.…”

“…T raumatic brain injury (TBI) remains as a serious public health problem (21). Tremendous attention has been paid due to its high mortality rate.…”

The hope for pandora\'s box: mesenchymal stem cells (mscs) for promoting angiogenesis in stroke and trauma brain injury

“…or diseased tissues via direct cell replacement (5). However, it soon became apparent that relatively few MSCs engrafted at these sites of injury, and studies in rodents and dogs confirmed that intravenously administered MSCs are caught in the capillaries of the lung, and most MSCs are largely cleared (1,8).…”