The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis

Abstract

Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P<0.05). However, the difference between Hashimoto hyperthyroidism group and Hashimoto hypothyroidism group has no statistical significance (P>0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.

Research on Renal Injury in Hashimoto&apos;s Thyroiditis Patients with Different Thyroid Function

“…Moreover, the cleavage fragments formed in the process of complement activation, such as C3a and C5a, can result in a variety of inflammatory effects and further aggravate the occurrence of renal injury. The levels of TPOAb and TGAb in Hashimoto hypothyroidism groupand Hashimoto sub-hypothyroidism group are distinctly higher than those in Hashimoto hyperthyroidism group and Hashimoto normal group [19], which may be another reason for the increase of urinary protein in Hashimoto hypothyroidism group and Hashimoto sub-hypothyroidism group.…”