The Rescue of the Romanian Health System by the Emergency Departments during the Fourth Wave of COVID-19 Pandemic

Opriţă, B; Davidoiu, Andrei; Dinu, Alexandru Bogdan; Opriță, Ruxandra

doi:10.3390/life12101547

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…We excluded 6 studies after reading their full texts. Of these studies, 3 included populations that did not meet the participants, interventions, comparisons, outcomes criteria, [15][16][17] and 3 duplicated data from other studies practically. [18][19][20] We performed a qualitative synthesis of the remaining 34 studies.…”

Section: Search Resultsmentioning

confidence: 99%

An updated systematic review and meta-analysis of fecal microbiota transplantation for the treatment of ulcerative colitis

Huang

Wang

et al. 2022

Medicine

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Background: Fecal microbiota transplantation (FMT) as a promising therapy for ulcerative colitis (UC) remains controversial. We conducted a systematic review and meta-analysis to assess the efficiency and safety of FMT as a treatment for UC. Methods:The target studies were identified by searching PubMed, EMBASE, the Cochrane Library, Web of Science, and ClinicalTrials and by manual supplementary retrieval. We conducted a general review and quantitative synthesis of included studies. We used the RevMan and Stata programs in the meta-analysis. The outcomes were total remission, clinical remission, steroid-free remission, and serious adverse events. We also performed subgroup analyses based on different populations.Results: A total of 34 articles were included in the general review. Only 16 articles, including 4 randomized controlled trials, 2 controlled clinical trials, and 10 cohort studies, were selected for the meta-analysis. We found that donor FMT might be more effective than placebo for attaining total remission (risk ratio [RR]: 2.77, 95% confidence interval [CI]: 1.54-4.98; P = .0007), clinical remission (RR: 0.33, 95% CI: 0.24-0.41; P < .05), and steroid-free remission (RR: 3.63, 95% CI: 1.57-8.42; P = .003), but found no statistically significant difference in the incidence of serious adverse events (RR: 0.88, 95% CI: 0.34-2.31, P = .8). The subgroup analyses revealed significant differences between the pooled clinical remission rates for different regions, degrees of severity of the disease, and patients with steroid-or nonsteroid-dependent UC.Conclusions: FMT can achieve clinical remission and clinical response in patients with UC.

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Section: Search Resultsmentioning

confidence: 99%

An updated systematic review and meta-analysis of fecal microbiota transplantation for the treatment of ulcerative colitis

Huang

Wang

et al. 2022

Medicine

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“…This study demonstrates that individuals admitted to the hospital for COVID-19 display incidents of arterial ischemic events, which serve as indicators of unfavourable prognosis. During the fourth wave in Romania, when the Delta B1217.2 variant of the SARS-CoV-2 virus was predominant, there was a notable increase in the number of patients with a severe form of the infection, as well as mortality amongst these individuals [39]. This increase was statistically significant, as can be seen in Figure 12.…”

Section: Comparison Of Covid-19 Pandemic Waves For Pe Groupmentioning

confidence: 88%

“…Severe COVID- 19 During the fourth wave in Romania, when the Delta B1217.2 variant of the SARS-CoV-2 virus was predominant, there was a notable increase in the number of patients with a severe form of the infection, as well as mortality amongst these individuals [39]. This increase was statistically significant, as can be seen in Figure 12.…”

Section: Comparison Of Covid-19 Pandemic Waves For Pe Groupmentioning

confidence: 93%

Risk Factors for Pulmonary Embolism in Individuals Infected with SARS-CoV2—A Single-Centre Retrospective Study

Herlo,

Marinescu,

Cut

et al. 2024

Biomedicines

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The emergence of SARS-CoV2 has presented itself as a significant global health crisis. The prevalence of thrombotic events is known to be high in these patients, affecting various organ systems, sometimes leading to cutaneous thrombosis, pulmonary embolism (PE), stroke, or coronary thrombosis. The available evidence suggests that thromboembolism, hypercoagulability, and the excessive production of proinflammatory cytokines play a significant role in the development of multiorgan failure. Methodology: This retrospective single-centre study was conducted at “Victor Babes” University of Medicine and Pharmacy from Timisoara, Romania, involving a total of 420 patients diagnosed with COVID-19. We separated them into a CONTROL group that included 319 patients, and an intervention group (PE) with 101 patients that, subsequent to infection with the virus, developed pulmonary embolism. The study included the reporting of demographic data, laboratory findings, and comorbidities. Results: Out of a total of 420 patients, 24% experienced pulmonary embolism, while 21.42% died. Arterial thrombotic events were found to be associated with factors such as age, cardiovascular disease, levels of white blood cells, D-dimers, and albumin in the blood. The findings of the study indicate that there is an independent association between pulmonary thrombosis and hypertension (odds ratio (OR): 1.1; 95% confidence interval (CI): 0.7 to 1.7; p = 0.6463), cancer (OR: 1.1; 95% CI: 0.6 to 2.3; p = 0.6014), and COPD (OR: 1.2; 95% CI: 0.6 to 2.3; p = 0.4927). On the other hand, there is a stronger correlation between PE and obesity (OR: 2.8; 95% CI: 1.7 to 4.6; p < 0.0001), diabetes (OR: 3.3; 95% CI: 2 to 5.3; p < 0.0001), and dyslipidemia (OR: 3.6; 95% CI: 2.3 to 5.8; p < 0.0001) in a multivariable regression logistic model. Conclusions: Patients diagnosed with severe forms of COVID-19 display a comparable incidence of arterial thrombotic events, which have been linked to poor survival rates.

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“…It is necessary to develop a quick, accurate scale to identify patients who are most at risk of dying. In the past, scoring systems have been applied to the healthcare system to stratify risk, predict outcomes, and e ciently manage patients (7). Numerous risk strati cation systems in COVID-19 are used to forecast death.…”

Section: Discussionmentioning

confidence: 99%

4C Mortality Score and CT Severity Score among COVID-19 Patients; A Single Center Prospective Study

Said

El-Fateh

Esmaeel

et al. 2023

Preprint

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Background Predictions about the hospital course of the coronavirus disease 2019 (COVID-19) patients are of paramount value. Objectives This research was designed to validate 4C mortality and CT severity scores (CT-SS) and detect their relations among patients with covid-19 who are hospitalized as prognostication tools. Patients and methods Two hundred and ninety-six confirmed COVID-19 cases were included. They were allocated into 3 groups according to severity;78 in non-severe group, 97 in severe group, and 121 patients in critical group. Patient demographics, clinical characteristics, co-morbidities, lines of treatment, 4C mortality score and CT severity score were assessed upon admission. Results The study revealed that 90% and 84.3% sensitivities were observed for both of 4C mortality and CT-SS respectively as predictors of mortality. Significant correlation between both scores (r = 0.6. p = 0.0001) was detected. Multivariate analysis identified 7-fold increased risk of mortality for the patients with 4C mortality score > 9.5 (p = 0.001). CT-SS > 12 (p = 0.02), age ≥ 60, male gender, hypertension and diabetes mellitus were also found as significant independent factors associated with increased mortality. Conclusion Satisfactory results were found on addition a verified radiological score to commonly used risk-stratification scores when estimating the probability of death in severe and critical cases in COVID-19.

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The Rescue of the Romanian Health System by the Emergency Departments during the Fourth Wave of COVID-19 Pandemic

Cited by 5 publications

References 36 publications

An updated systematic review and meta-analysis of fecal microbiota transplantation for the treatment of ulcerative colitis

An updated systematic review and meta-analysis of fecal microbiota transplantation for the treatment of ulcerative colitis

Risk Factors for Pulmonary Embolism in Individuals Infected with SARS-CoV2—A Single-Centre Retrospective Study

4C Mortality Score and CT Severity Score among COVID-19 Patients; A Single Center Prospective Study

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