The reproductive side effects of Imidacloprid in pregnant Wistar rat

Nabiuni, Mohammad; Kazem, Parivar; Noorinejad, Rooholah; Falahati, Zahra; Khalili, Faezeh; Karimzadeh, L

doi:10.5899/2015/ijcmb-00017

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…and non-pregnant mice in corresponding ages on one day treated groups of 10, 15, and 20 mg/kg/d. These results are consistent with the results indicated that imidacloprid was rapidly absorbed and distributed throughout the body and more than 90 % of IMI was eliminated in the urine and feces in the first 48 hours following exposure (Nabiuni, et al,. 2015).…”

Section: Discussionsupporting

confidence: 91%

Effects of Imidacloprid and Gestational Age on Biodistribution and Maternal Toxicity in Pregnant Mice Compared to Non- Pregnant

Farag

Abou-Elnasr

khafagy³

et al. 2021

Alexandria Science Exchange Journal

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Section: Discussionsupporting

confidence: 91%

Effects of Imidacloprid and Gestational Age on Biodistribution and Maternal Toxicity in Pregnant Mice Compared to Non- Pregnant

Farag

Abou-Elnasr

khafagy³

et al. 2021

Alexandria Science Exchange Journal

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“…Studies conducted in male and female laboratory animals, mostly rats, have established that oral administration of imidacloprid could affect reproductive function, as summarised in Table 1 (20)(21)(22)(23)(24)(25)(26)(27)(28). Subchronic and chronic exposure to different doses of imidacloprid can cause histological damage of the testicular tissue, changes in sperm morphology, increased sperm mortality and abnormality, decreased sperm count and motility, inhibited spermatogenesis, and reduced testosterone levels in male rats, all of which could lead to infertility (20)(21)(22)(23)(24).…”

Section: Reproductive Toxicitymentioning

confidence: 99%

“…Reproductive toxicity of imidacloprid was also studied following in utero exposure of the female offspring of pregnant rats receiving 10 mg kg -1 bw of imidacloprid through the tail vein from gestation day 7 to 21 (26). The offspring showed disrupted follicular development, lower oestradiol and progesterone levels, lower ovarian weight and diameter as well as decrease in the rate of successful mating and reduction in foetal number due to downregulation of ovarian DAX1 gene compared to controls.…”

Section: =First/second Generation Of Offspring; Fsh=follicular Stimumentioning

confidence: 99%

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Mikolić

Karačonji

2018

Archives of Industrial Hygiene and Toxicology

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Imidacloprid, a neonicotinoid insecticide, has been used worldwide due to its selective toxicity for insects. Its residues may enter the food chain, which is why it is important to investigate the potential adverse effects of imidacloprid exposure. This review summarises current knowledge of the reproductive toxicity and disruptive endocrine effects of imidacloprid in laboratory animals. Investigations, conducted mostly on laboratory rats, have shown adverse effects of imidacloprid on the reproductive ability in both parental and offspring generation as well as on the development of the offspring. Like many pesticides, imidacloprid may also act as endocrine disrupting chemical (EDC). It may disrupt the metabolic homeostasis, contribute to obesity, and disrupt steroidogenesis by inhibiting cytochrome P450 (CYP) enzyme activities. All these adverse effects of imidacloprid may pose a serious risk for reproduction and development with long-term consequences in adulthood.

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“…It also acts as an endocrine disruptor, and thus, increases FSH level, while decreases LH and progesterone content (El-Gendy et al 2010;Kapoor et al 2011). IMI disrupts follicular development via the down-regulation of ovarian DAX1 (Nabiuni et al 2015).…”

Section: Imidacloprid (Imi)mentioning

confidence: 99%

“…It also induces pathomorphological changes in ovarian follicles such as cytoplasmic clumping and abundant lipofuscin elements in granulosa cells (Kapoor et al ). IMI decreases ovarian weight, ovarian diameter, follicle number, follicular diameter, pregnancy rate, estradiol and progesterone content, and DAX1 expression (the gene associated with ovarian follicular growth) in the offspring of the exposed female rat (Nabiuni et al ). Administration of IMI also increases the frequency of atretic follicle.…”

Section: Insecticides‐induced Ovarian Dysfunctionmentioning

confidence: 99%

Insecticides and ovarian functions

Sharma

Singh

Setia

et al. 2020

Environ and Mol Mutagen

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Insecticides, a heterogeneous group of chemicals, are widely used in agriculture and household practices to avoid insect‐inflicted damage. Extensive use of insecticides has contributed substantially to agricultural production and the prevention of deadly diseases by destroying their vectors. On the contrary, many of the insecticides are associated with several adverse health effects like neurological and psychological diseases, metabolic disorders, hormonal imbalance, and even cancer in non‐target species, including humans. Reproduction, a very selective process that ensures the continuity of species, is affected to a greater extent by the rampant use of insecticides. In females, exposure to insecticides leads to reproductive incapacitation primarily through disturbances in ovarian physiology. Disturbed ovarian activities encompass the alterations in hormone synthesis, follicular maturation, ovulation process, and ovarian cycle, which eventually lead to decline in fertility, prolonged time‐to‐conceive, spontaneous abortion, stillbirths, and developmental defects. Insecticide‐induced ovarian toxicity is effectuated by endocrine disruption and oxidative stress. Oxidative stress, which occurs due to suppression of antioxidant defense system, and upsurge of reactive oxygen and nitrogen species, potentiates DNA damage and expression of apoptotic and inflammatory markers. Insecticide exposure, in part, is responsible for ovarian malfunctioning through disruption of hypothalamic–pituitary–gonadal axis. The current article is focused on the adverse effects of insecticides on ovarian functioning, and consequently, on the reproductive efficacy of females. The possible strategies to combat insecticide‐induced toxicity are also discussed in the latter part of this review. Environ. Mol. Mutagen. 61:369–392, 2020. © 2020 Wiley Periodicals, Inc.

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The reproductive side effects of Imidacloprid in pregnant Wistar rat

Cited by 7 publications

References 24 publications

Effects of Imidacloprid and Gestational Age on Biodistribution and Maternal Toxicity in Pregnant Mice Compared to Non- Pregnant

Effects of Imidacloprid and Gestational Age on Biodistribution and Maternal Toxicity in Pregnant Mice Compared to Non- Pregnant

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Insecticides and ovarian functions

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