The Reproducibility of the Prolactin Response to Buspirone

Tg, Dinan; Barry, Siobhan; Ln, Yatham; Mobayed, Mamoun; O'Hanlon, Mary S

doi:10.1097/00004850-199004000-00006

Cited by 40 publications

(16 citation statements)

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“…No differences were found and so, because of the small number of subjects, the two were combined. Other authors have found fluctuations in 5-HT responsivity in women through the menstrual cycle (Dinan et al, 1990;O'Keane, O'Hanlon and Webb, 1991). This did not appear to affect our results but may be a greater problem in a between-individuals design.…”

Section: Discussioncontrasting

confidence: 51%

The effects of D-fenfluramine on mood and performance, and on neuroendocrine indicators of 5-HT function

Bond

Feizollah²,

Lader

1995

J Psychopharmacol

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D-fenfluramine has multiple actions which enhance 5-HT transmission and make it a useful neuroendocrine challenge agent, but little is known of its effects on mood or performance. In this study, two doses (15 and 30 mg) and placebo were administered to six male and six female healthy volunteers according to a double blind, cross-over design. Blood was sampled and self-ratings completed pre- and hourly up to 5 h post-challenge. Performance tests were administered pre- and at 2 and 4 h. Plasma concentrations of prolactin and cortisol decreased after all treatments at 1 h and then increased post-drug to a peak at 4 h. Body temperature showed a similar pattern. D-fenfluramine was well tolerated with few side effects. It caused only minor sedation and little psychomotor impairment but there was some decrement in episodic memory. The 30 mg dose produced a mild anxiolytic and anti-aggressive action.

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Section: Discussioncontrasting

confidence: 51%

The effects of D-fenfluramine on mood and performance, and on neuroendocrine indicators of 5-HT function

Bond

Feizollah²,

Lader

1995

J Psychopharmacol

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“…In addition, Dinan et al (1990) found significantly increased PRL responses to the 5-HTIA receptor agonist buspirone during the high oestrogen part of the menstrual cycle, though the status of the PRL response to buspirone as measure of 5-HT1A receptor sensitivity is controversial (Meltzer et al, 1982;Anderson and Cowen, 1992).…”

Section: Resultsmentioning

confidence: 99%

Effect of oestradiol treatment on 5-HT and dopamine-mediated neuroendocrine responses

et al. 1992

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We assessed the effect of oestradiol treatment in women on the endocrine responses to the 5-hydroxytryptamine (5-HT) precursor, L-tryptophan (LTP) (5 g i.v.) and the dopamine agonist, apomorphine (0.005 mg/kg s.c.). Following oestradiol implant (100 mg s.c.) the prolactin (PRL) response to LTP was significantly enhanced but there was no change in the growth hormone (GH) response to apomorphine. There was, however, a significant correlation between post-implant oestradiol concentrations and post-implant apomorphine-induced GH release. The results indicate that oestrogen treatment may facilitate 5-HT-mediated PRL release and could also influence the regulation of dopamine-mediated GH responses. However, further studies are needed to exclude direct effects of oestradiol on the pituitary release of PRL and GH.

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“…These agents are able to induce a release of some hormones such as growth hormone (GH), prolactin (PRL), adrenocorticotropin (ACTH) or cortisol, and a decrease in body temperature. Studies with the 5-HT 1A receptor partial agonist buspirone have reported a significant PRL release (Meltzer et al 1983;Coccaro et al 1990;Dinan et al 1990;Anderson and Cowen 1992;Bridge et al 2001), but recent data have shown the importance of dopaminergic effects of the drug in the induction of PRL release (Bridge et al 2001). Stimulation of the hypothalamo-pituitary-adrenal axis (HPA) by the 5-HT 1A agonist ipsapirone has been demonstrated in several studies (Kahn et al 1994;Meltzer and Maes 1995a;Gelfin et al 1995;Cleare et al 1998;Schwartz et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Hormonal and temperature responses to the 5-HT 1A receptor agonist flesinoxan in normal volunteers

Pitchot¹,

Wauthy²,

Hansenne³

et al. 2002

Psychopharmacology

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Rationale: Flesinoxan is a highly potent and selective 5-HT 1A agonist and appears to be a potentially interesting neuroendocrine serotonergic probe. Objectives: We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers. Methods: In a doubleblind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min. Results: Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent. Conclusions: These results showed the role of 5-HT 1A mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.

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The Reproducibility of the Prolactin Response to Buspirone

Cited by 40 publications

References 0 publications

The effects of D-fenfluramine on mood and performance, and on neuroendocrine indicators of 5-HT function

The effects of D-fenfluramine on mood and performance, and on neuroendocrine indicators of 5-HT function

Effect of oestradiol treatment on 5-HT and dopamine-mediated neuroendocrine responses

Hormonal and temperature responses to the 5-HT 1A receptor agonist flesinoxan in normal volunteers

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