The reproducibility of color Doppler duplex sonography in the measurement of renal arterial blood velocity

Assessment of Early Tumor Response to Cytotoxic Chemotherapy with Dynamic Contrast-Enhanced Ultrasound in Human Breast Cancer Xenografts

“…Since color and spectral Doppler ultrasound allows semiquantitative assessment of tumor vascularity, measurements of peak systolic velocity, end-diastolic velocity, resistivity index and pulsatility index have shown the potential to serve as a functional tool for monitoring tumor response to chemotherapy [27]–[29]. However, the high degree of subjectivity as well as its lack of reproducibility makes it impossible to gain wide acceptance in clinical practice [30]. With the wide application of ultrasound contrast agents in clinical practice, CEUS has recently improved the US diagnostics of several diseases, especially in the differentiation of liver lesions [31].…”

Contrast-Enhanced Gray-Scale Ultrasound for Quantitative Evaluation of Tumor Response to Chemotherapy: Preliminary Results With a Mouse Hepatoma Model

“…Color Doppler ultrasound can be used for objective semiquantitative assessment of tumor vascularity, and measurement of peak systolic velocity, end-diastolic velocity, resistivity index, and pulsatility index has been found to have potential as a functional tool for monitoring tumor response to chemotherapy [19][20][21]. However, measurement with color Doppler ultrasound has not gained wide acceptance because of the high degree of subjectivity and lack of reproducibility [22]. Furthermore, even with the use of contrast agents, power Doppler imaging does not depict capillary blood flow [9], an essential precondition for quantifying tissue perfusion.…”

Colour doppler ultrasound of the lumbar arteries: A novel application and reproducibility study in healthy subjects

“…Baumgartner et al (1999)) reported good agreement between observers for measurement of renal artery PSV, but emphasised the need for experience to obtain more reliable results. Imuta et al (1997) reported very good inter-and intraobserver reproducibility for PSV measurements in the interlobar arteries. They standardised the physiological conditions of all subjects for 30 min before each examination and this likely contributed to their good results.…”

“…With this, it has been extensively applied to examine flow velocity in very small arteries, such as tumour vessels, renal interlobar arteries, vessels of the penis and scrotum and digital arteries, for example (Cosgrove et al 1993;Imuta et al 1997;Wilkins et al 2003;Sidhu 1999;Humphries et al 1999).…”