The repeated administration of rhIL‐12 for 14 weeks in rhesus monkeys: A toxicity assessment
Huiqin Ding,
Huan Qin,
Jiangang Wang
et al.
Abstract:Interleukin‐12 (IL‐12) is known to exert antitumor immune effects by promoting the activation and proliferation of T cells and NK cells within the immune system. However, clinical trials have observed systemic toxicity associated with the administration of IL‐12. This has shelved development plans for its use as a cancer therapeutic drug. Therefore, it is critical that we perform a systematic evaluation of the toxicity and safety of repeated IL‐12 administration. In this study, we conducted a comprehensive eva… Show more
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