The repair of impaired epidermal barrier function in rats by the cutaneous application of linoleic acid

Prottey, C.; Hartop, P.J.; Black, J.G.; McCORMACK, J.I.

doi:10.1111/j.1365-2133.1976.tb04336.x

Cited by 70 publications

(25 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Topical Emollient Therapymentioning

confidence: 99%

“…597,598 Cutaneous absorption and metabolism of linoleic acid seemed largely responsible for the beneficial effects of sunflower-seed oil. 490,[598][599][600] Topical therapy with sunflower-seed oil has also been found to correct cutaneous signs of EFA deficiency (ie, normalization of TEWL, resolution of dermatitis) in humans, including premature infants. 598,601,602 It has been ad-vanced that these beneficial effects may be due to increased metabolism of lipids in the epidermis, including active fatty-acid transport by keratinocytes, which makes it possible for even the immature epidermis of preterm infants to metabolize lipids derived from topically applied emollients and to utilize them as nutritional building blocks for the formation of a healthy, functional epidermal barrier.…”

Section: Topical Emollient Therapymentioning

confidence: 99%

See 1 more Smart Citation

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

View full text Add to dashboard Cite

ABSTRACT. Background. Infant and under-5 childhood mortality rates in developing countries have declined significantly in the past 2 to 3 decades. However, 2 critical indicators, maternal and newborn mortality, have hardly changed. World leaders at the United Nations Millennium Summit in September 2000 agreed on a critical goal to reduce deaths of children <5 years by two thirds, but this may be unattainable without halving newborn deaths, which now comprise 40% of all under-5 deaths. Greater emphasis on wide-scale implementation of proven, cost-effective measures is required to save women's and newborns' lives. Approximately 99% of neonatal deaths take place in developing countries, mostly in homes and communities. A comprehensive review of the evidence base for impact of interventions on neonatal health and survival in developingcountry communities has not been reported.Objective. This review of community-based antenatal, intrapartum, and postnatal intervention trials in developing countries aimed to identify (1) key behaviors and interventions for which the weight of evidence is sufficient to recommend their inclusion in communitybased neonatal care programs and (2) key gaps in knowledge and priority areas for future research and program learning.Methods. Available published and unpublished data on the impact of community-based strategies and interventions on perinatal and neonatal health status outcomes were reviewed. Evidence was summarized systematically and categorized into 4 levels of evidence based on study size, location, design, and reported impact, particularly on perinatal or neonatal mortality. The evidence was placed in the context of biological plausibility of the intervention; evidence from relevant developed-country studies; health care program experience in implementation; and recommendations from the World Health Organization and other leading agencies.Results. A paucity of community-based data was found from developing-country studies on health status impact for many interventions currently being considered for inclusion in neonatal health programs. However, review of the evidence and consideration of the broader context of knowledge, experience, and recommendations regarding these interventions enabled us to categorize them according to the strength of the evidence base and confidence regarding their inclusion now in programs. This article identifies a package of priority interventions to include in programs and formulates research priorities for advancing the state of the art in neonatal health care.Conclusions. This review emphasizes some new findings while recommending an integrated approach to safe motherhood and newborn health. The results of this study provide a foundation for policies and programs related to maternal and newborn health and emphasizes the importance of health systems research and evaluation of interventions. The review offers compelling support for using research to identify the most effective measures to save newborn lives. It also may facilitate dialogue with policy...

show abstract

Section: Topical Emollient Therapymentioning

confidence: 99%

Section: Topical Emollient Therapymentioning

confidence: 99%

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

et al. 2005

View full text Add to dashboard Cite

show abstract

“…22 ) also reported that dietary fish oil lacked the capacity to reverse the signs of dorsal epidermal disease characteristic of EFA deprivation. The decrease in water consumption by increased supply of the EPA concentrate to the 0.25EPA group may suggest that EPA has EFA-functional character in the skin, because the content of· LA, which prevents transepidermal water loss, 23,24) in the EPA concentrate was negligible (Table I).…”

Section: Discussionmentioning

confidence: 94%

Dietary Effects of n-3 Eicosapentaenoic Acid on Essential Fatty Acid-deficiency Symptoms of Rats

Takeuchi¹,

Inoue

Yoshida

et al. 1989

Agricultural and Biological Chemistry

View full text Add to dashboard Cite

“…Essential fatty acids (EFAs), in particular linoleic and γ-linolenic (18: 3n-6) acids, are essential for the construction and the repair of the skin lipidic barrier (Hansen and Jensen, 1985;Ziboh and Chapkin, 1987). Linoleic acid has a crucial role in the synthesis of acylglucosylceramides and thereby has the essential function in maintaining the integrity of the epidermal water permeability barrier Prottey et al, 1976). For these reasons, linoleic acid has been used for the treatment of acne vulgaris (Gareiss et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Synthesis of α‐Butylglucoside Linoleate in a Packed Bed Reactor for Future Pilot Scale‐up

Bousquet

Willemot

Monsan

et al. 2000

Biotechnology Progress

View full text Add to dashboard Cite

The enzymatic synthesis of a mixture of unsaturated fatty acid alpha-butylglucoside esters, containing more than 60% alpha-butylglucoside linoleate, was achieved through lipase-catalyzed esterification. The continuous evaporation under reduced pressure of the water produced enabled substrate conversions greater than 95% to be reached. Two immobilized lipases from Candida antarctica (Chirazyme L2, c.-f., C2) and Rhizomucor miehei (Chirazyme L9, c.-f.) were compared in stirred batch and packed bed configurations. When the synthesis was carried out in stirred batch mode, C. antarctica lipase appeared to be of greater interest than the R. miehei enzyme in terms of stability and regioselectivity. Surprisingly, a change in the process design to a packed bed configuration enabled the stability of R. miehei lipase to be significantly improved, while the C. antarctica lipase efficiency to synthesize unsaturated fatty acid alpha-butylglucoside esters was slightly decreased. Water content in the microenvironment of the biocatalyst was assumed to be responsible for such changes. When the process is run in stirred batch mode, the conditions used promote the evaporation of the essential water surrounding the enzyme, which probably leads to R. miehei lipase dehydration. In contrast, the packed bed design enabled such water evaporation in the microenvironment of the biocatalyt to be avoided, which resulted in a tremendous improvement of R. miehei lipase stability. However, C. antarctica lipase led to the formation of 3% diesters, whereas the final percentage of diesters reached 21% when R. miehei enzyme was used as biocatalyst. A low content of diesters is of greater interest in terms of alpha-butylglucoside linoleate application as linoleic acid carrier, and therefore the enzyme choice will have to be made depending on the properties expected for the final product.

show abstract

The repair of impaired epidermal barrier function in rats by the cutaneous application of linoleic acid

Cited by 70 publications

References 19 publications

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries: A Review of the Evidence

Dietary Effects of n-3 Eicosapentaenoic Acid on Essential Fatty Acid-deficiency Symptoms of Rats

Enzymatic Synthesis of α‐Butylglucoside Linoleate in a Packed Bed Reactor for Future Pilot Scale‐up

Contact Info

Product

Resources

About