The repair of brain lesion by implantation of hyaluronic acid hydrogels modified with laminin

Harnessing the Potential of Biomaterials for Brain Repair after Stroke

“…The materials themselves offer some neuroprotection by providing structural support, attenuating gliosis and inflammation, and reducing cavitation. Bioactive materials, like HA, reduce inflammation through the CD44 receptor by inhibiting leukocyte migration and inflammation (Forrester and Wilkinson, 1981;Cooper et al, 2008), resulting in reduced microglial activation (Wang et al, 2012b) and stroke infarct volume (Hou et al, 2005;Austin et al, 2012;Wang et al, 2013;Tuladhar et al, 2015).…”

Laminin Enriched Scaffolds for Tissue Engineering Applications

“…The scaffolds showed astrocyte and microglial infiltration as well as angiogenesis but only LM modified scaffolds showed neurite outgrowth and the presence of myelinated nerve fibers in the regenerating tissue. 54 Arulmoli et al 55 combined fibrin, HA and LM (100µg/ml) to create combination scaffolds for the purpose of NPSC transplantation following CNS injury. The addition of LM significantly improved neurite outgrowth from differentiating NPSCs.…”

Overview on Biocompatibilities of Implantable Biomaterials

“…Praveen and coworkers used HA/polyvinyl alcohol (PVA) coating membrane to minimize the problems related to protein deposition and fibrous tissue formation on an implanted glucose sensor [90]. HA hydrogels modified with laminin could support cell infiltration, angiogenesis, and simultaneously inhibit the formation of glial scar after being implanted into the lesion of the cortex [91]. Compared with pure gelatin hydrogen, HA/gelatin composite has a better compatibility and contiguity with the surrounding brain tissue with no inflammatory reaction and fibrous encapsulation [92].…”